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Peptide Transport and Delivery into the Central Nervous System

  • Book
  • © 2003

Overview

Editors:
  1. Laszlo Prokai

    1. Department of Medicinal Chemistry, College of Pharmacy and The McKnight Brain Institute, University of Florida, Gainesville, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Katalin Prokai-Tatrai

    1. Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Discusses strategies to overcome the blood-brain-barrier
  • Comparative evaluation of the present state of drug delivery strategies
  • Biological carriers, prodrug and chemical delivery/targeting strategies are presented
  • Includes supplementary material: sn.pub/extras

Part of the book series: Progress in Drug Research (PDR, volume 61)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-viii
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  2. Neuropeptides: general characteristics and neuropharmaceutical potential in treating CNS disorders

    • Fleur L. Strand
    Pages 1-37

  3. Structural and functional aspects of the blood-brain barrier

    • David J. Begley, Milton W. Brightman
    Pages 39-78

  4. Peptide transport across the blood-brain barrier

    • Abba J. Kastin, Weihong Pan
    Pages 79-100

  5. Intracranial delivery of proteins and peptides as a therapy for neurodegenerative diseases

    • Richard Grondin, Zhiming Zhang, Yi Ai, Don M. Gash, Greg A. Gerhardt
    Pages 101-123

  6. Altering the properties of the blood-brain barrier: disruption and permeabilization

    • David Fortin
    Pages 125-154

  7. Modifying peptide properties by prodrug design for enhanced transport into the CNS

    • Katalin Prokai-Tatrai, Laszlo Prokai
    Pages 155-188

  8. CNS-delivery via conjugation to biological carriers: physiological-based approaches

    • Suresh P. Vyas
    Pages 189-219

  9. Peptide vectors as drug carriers

    • Jamal Temsamani, Jean-Michel Scherrmann
    Pages 221-238

  10. Back Matter

    Pages 239-245
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Keywords

About this book

Hypo- or hypersecretion, alteration in storage, release, catabolism, and post-translational processing of neuropeptides are associated with the etiology of many diseases affecting the central nervous system (CNS). Various peptides native to the brain and the spinal cord, as well as various synthetic peptides, peptide analogues and peptidomimetics developed as their agonists or antagonists could be useful in the treatment of these CNS maladies. However, peptides face a formidable obstacle in reaching the intended site of action due to the existence of the blood-brain barrier (BBB), a vital element in the regulation of the internal environment of the brain and the spinal cord. After reviews on the role and neuropharmaceutical potential of peptides, properties of the BBB in the context of peptide transport in the CNS and potential transport mechanisms to cross the BBB, this volume discusses the development, present state-of-the-art and future trends of various strategies to overcome this major obstacle to peptide pharmacotherapy involving the CNS. Chapters are devoted to cover invasive approaches that circumvent the BBB by direct administration into the brain or the spinal cord and by transiently opening the tight junctions of or permeabilizing the endothelial cells separating the systemic circulation from the interstitial fluid of the CNS. Subsequently, physiologically based strategies that utilize biological carriers to gain access to the CNS are discussed in detail, followed by methods encompassing prodrug and chemical delivery/targeting strategies, which aim at altering the properties of the peptide to enhance BBB transport, and drug delivery strategies based on peptide vectors. Finally, a comparative evaluation on the present status and perspectives of the techniques is presented.

Editors and Affiliations

  • Department of Medicinal Chemistry, College of Pharmacy and The McKnight Brain Institute, University of Florida, Gainesville, USA

    Laszlo Prokai

  • Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, USA

    Katalin Prokai-Tatrai

Bibliographic Information

  • Book Title: Peptide Transport and Delivery into the Central Nervous System

  • Editors: Laszlo Prokai, Katalin Prokai-Tatrai

  • Series Title: Progress in Drug Research

  • DOI: https://doi.org/10.1007/978-3-0348-8049-7

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Basel AG 2003

  • Softcover ISBN: 978-3-0348-9420-3Published: 07 November 2012

  • eBook ISBN: 978-3-0348-8049-7Published: 06 December 2012

  • Series ISSN: 0071-786X

  • Series E-ISSN: 2297-4555

  • Edition Number: 1

  • Number of Pages: VIII, 245

  • Topics: Pharmacology/Toxicology, Medicine/Public Health, general, Life Sciences, general

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