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Nonselective Cation Channels

Pharmacology, Physiology and Biophysics

  • Book
  • © 1993

Overview

Editors:
  1. Detlef Siemen

    1. Institut für Zoologie, Universität Regensburg, Regensburg, Germany

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  2. Jürgen Hescheler

    1. Institut für Pharmakologie, Freie Universität Berlin, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Experientia Supplementum (EXS, volume 66)

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. Nonselective Cation Channels

      • Detlef Siemen
      Pages 3-25

    3. Nonselective Cation Channels: Physiological and Pharmacological Modulations of Channel Activity

      • J. Hescheler, G. Schultz
      Pages 27-43

  5. Gap Junction Channels

    1. Front Matter

      Pages 107-107
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    2. The Gap Junction Channel

      • Rolf Dermietzel
      Pages 109-117

  7. Channels Activated by Intracellular Calcium

    1. Front Matter

      Pages 173-173
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    2. Control of Cell Function by Neuronal Calcium-Activated Nonselective (CAN) Cation Channels

      • L. Donald Partridge, Dieter Swandulla
      Pages 175-183
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Keywords

About this book

It can be argued that nonselective cation channels were the first sort of ion channel to be described, though the word channel was not used at the time. Their existence was implied by Fatt and Katz in 1952, when they described the action of acetylcholine at the muscle endplate as producing "a large nonselective increase of ion permeability, i.e. a short circuit". Shortly afterwards, in 1956, Katz referred to "aqueous channels through which small ions can pass ... " (del Castillo and Katz, Prog. Biophysics and Biophys. Chern. 6, 121-170). Now, more than thirty years later, it has become clear that there are far more types of nonselective cation channels than anyone could have imagined a few years ago, and that they are found in a vast range of tissues. One has, of course, become quite accustomed to such diversity in, for example, GABA receptors, but this is not quite the same thing. A In the case of GABAA receptor we are talking about a fairly narrow range of structural diversity (resulting largely from differences in subunit composition) within a single type of channel with more-or-Iess well­ defined function. In the case of nonselective cation channels the function is often not known, and relatively few have been cloned. It seems certain though, that they encompass a wide range of quite different structural types.

Editors and Affiliations

  • Institut für Zoologie, Universität Regensburg, Regensburg, Germany

    Detlef Siemen

  • Institut für Pharmakologie, Freie Universität Berlin, Berlin, Germany

    Jürgen Hescheler

Bibliographic Information

  • Book Title: Nonselective Cation Channels

  • Book Subtitle: Pharmacology, Physiology and Biophysics

  • Editors: Detlef Siemen, Jürgen Hescheler

  • Series Title: Experientia Supplementum

  • DOI: https://doi.org/10.1007/978-3-0348-7327-7

  • Publisher: Birkhäuser Basel

  • eBook Packages: Springer Book Archive

  • Copyright Information: Birkhäuser Verlag 1993

  • Softcover ISBN: 978-3-0348-7329-1Published: 13 March 2012

  • eBook ISBN: 978-3-0348-7327-7Published: 08 March 2013

  • Series ISSN: 1664-431X

  • Series E-ISSN: 2504-3692

  • Edition Number: 1

  • Number of Pages: XIV, 320

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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