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Telomerase Inhibition

Strategies and Protocols

  • Book
  • © 2007

Overview

Editors:
  1. Lucy G. Andrews

    1. Department of Biology, University of Alabama at Birmingham, Birmingham

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    You can also search for this editor in PubMed   Google Scholar

  2. Trygve O. Tollefsbol

    1. Department of Biology, University of Alabama at Birmingham, Birmingham

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    You can also search for this editor in PubMed   Google Scholar

  • A compendium of the most recent and advanced methods applied to the rapidly expanding field of telomerase inhibition
  • Provides the researcher with a diverse and comprehensive set of tools

Part of the book series: Methods in Molecular Biology (MIMB, volume 405)

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Table of contents (14 protocols)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Methods of Telomerase Inhibition

    • Lucy G. Andrews, Trygve O. Tollefsbol
    Pages 1-8

  3. Telomerase Inhibition by Synthetic Nucleic Acids and Chemosensitization in Human Bladder Cancer Cell Lines

    • Kai Kraemer, Susanne Fuessel, Axel Meye
    Pages 9-22

  4. hTERT Knockdown in Human Embryonic Kidney Cells Using Double-Stranded RNA

    • Serene R. Lai, Lucy G. Andrews, Trygve O. Tollefsbol
    Pages 23-29

  5. RNA Interference Using a Plasmid Construct Expressing Short-Hairpin RNA

    • Serene R Lai, Lucy G Andrews, Trygve O Tollefsbol
    Pages 31-37

  6. Retrovirus-Mediated RNA Interference

    • Amanda P. Cunningham, Lucy G. Andrews, Trygve O. Tollefsbol
    Pages 39-46

  7. Telomerase Inhibition and Telomere Targeting in Hematopoietic Cancer Cell Lines with Small Non-Nucleosidic Synthetic Compounds (BIBR1532)

    • Hesham El Daly, Uwe M. Martens
    Pages 47-60

  8. Uses of Telomerase Peptides in Anti-Tumor Immune Therapy

    • He Li, Indzi Katik, Jun-Ping Liu
    Pages 61-86

  9. Establishing Cell-Based Reporter Systems for the Analysis of hTERT Expression

    • Yi-Yuan Huang, Jing-Wen Shih, Jing-Jer Lin
    Pages 87-96

  10. Telomerase RNA Inhibition Using Antisense Oligonucleotide Against Human Telomerase RNA Linked to a 2′,5′-Oligoadenylate

    • Yasuko Kondo, Seiji Kondo
    Pages 97-112

  11. Knockdown of Telomerase RNA Using Hammerhead Ribozymes and RNA Interference

    • Shang Li, Mehdi Nosrati, Mohammed Kashani-Sabet
    Pages 113-131

  12. Evaluation of Tankyrase Inhibition in Whole Cells

    • Tomokazu Ohishi, Takashi Tsuruo, Hiroyuki Seimiya
    Pages 133-146

  13. Inhibition of Telomerase by Targeting MAP Kinase Signaling

    • Dakang Xu, He Li, Jun-Ping Liu
    Pages 147-165

  14. Screening of Telomerase Inhibitors

    • Elke Kleideiter, Kamilla Piotrowska, Ulrich Klotz
    Pages 167-180

  15. Telomerase Inhibition Combined with Other Chemotherapeutic Reagents to Enhance Anti-Cancer Effect

    • Tetsuzo Tauchi, Junko H. Ohyashiki, Kazuma Ohyashiki
    Pages 181-189

  16. Back Matter

    Pages 191-193
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Keywords

About this book

Due in part to the selective nature of telomerase inhibition as an anticancer approach, the field has expanded considerably in the past decade. The recent advances in methods of telomerase inhibition encompass many different areas of research including molecular biology, cell biology, biochemistry, oncology and gerontology. Telomerase Inhibition provides methods and protocols for those researchers. The techniques described in this book should provide the researcher with a diverse and comprehensive set of tools with which to study telomerase inhibition. Leaders in the field provide recently developed methods that have widespread application such as targeting the telomerase holoenzyme, its RNA template and other elements associated with telomerase activity. Additional methods involving the screening of telomerase inhibitors and telomerase inhibition combined with other chemotherapeutic agents are presented. This text, on the cutting edge of the field, will provide investigators with the most recent methods applied to the expanding field of telomerase inhibition.

Reviews

From the reviews:

"This book contains 14 chapters by active players in the telomerase field. … Overall this book will be a useful resource for researchers performing telomerase-related experiments." (Lionel Guittat and Jean-Louis Mergny, ChemMedChem, Issue 3, 2008)

Editors and Affiliations

  • Department of Biology, University of Alabama at Birmingham, Birmingham

    Lucy G. Andrews, Trygve O. Tollefsbol

Bibliographic Information

  • Book Title: Telomerase Inhibition

  • Book Subtitle: Strategies and Protocols

  • Editors: Lucy G. Andrews, Trygve O. Tollefsbol

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-60327-070-0

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Protocols

  • Copyright Information: Humana Press 2007

  • Hardcover ISBN: 978-1-58829-683-2Published: 29 November 2007

  • Softcover ISBN: 978-1-61737-716-7Published: 12 December 2011

  • eBook ISBN: 978-1-60327-070-0Published: 03 February 2008

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: X, 193

  • Topics: Cell Biology, Cancer Research, Human Genetics, Biochemistry, general

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