Overview
- Editors:
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Jian-Ying Wang
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Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore
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Robert A. Casero
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The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore
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Table of contents (27 chapters)
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Polyamines in Signal Transduction of Cell Proliferation
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- Allan A. Ancheta, Leo Hawel III, Craig V. Byus
Pages 25-40
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- Cheryl A. Hobbs, Susan K. Gilmour
Pages 75-89
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- Sripriya Venkiteswaran, Thresia Thomas, T. J. Thomas
Pages 91-122
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- Lisa M. Shantz, Emanuele Giordano
Pages 123-137
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- Raymond G. Schipper, Vincent Cuijpers, Johannes C. Romijn, Albert A. J. Verhofstad
Pages 155-168
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- Jack W. Olson, Mark N. Gillespie
Pages 187-202
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Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy
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Front Matter
Pages 203-203
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- Robert A. Casero Jr., Alison V. Fraser, Tracy Murray-Stewart, Amy Hacker, Naveen Babbar, Jennifer Fleischer et al.
Pages 205-232
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- Leonard R. Johnson, Ramesh M. Ray
Pages 233-248
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- Jonas A. Nilsson, John L. Cleveland
Pages 249-266
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- Heather M. Wallace, Alun Hughes
Pages 267-278
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- Denis Soulet, Serge Rivest
Pages 279-292
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- Rupesh Chaturvedi, Keith T. Wilson
Pages 293-312
About this book
Polyamines are organic cations found in all eukaryotic cells and intimately involved in, and required for, distinct biological functions. An increasing body of evidence indicates that the regulation of cellular polyamines is a central convergence point for the multiple signaling pathways driving various cellular functions. Over the last decade, considerable progress has been made in und- standing the molecular functions of cellular polyamines. These significant findings provide a fundamental basis to not only define the exact role of polyamines in physiology, but also to develop new therapeutic approaches for cancers and other diseases. The major objective of this book is to provide a timely and long lasting guide for investigators in the fields of polyamines, physiology, pharmacology, and cancer research. It will provide a foundation based on research and address the potential for subsequent applications in clinical practice. Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research is divided into four main parts: Part I: Polyamines in Signal Transduction of Cell Proliferation Part II: Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy Part III: Polyamines in Cell Motility and Cell–Cell Interactions Part IV: Polyamine Homeostasis and Transport This book not only covers the current state-of-the-art findings relevant to cellular and molecular functions of polyamines, but also provides the underlying conceptual basis and knowledge regarding potential therapeutic targeting of polyamines and polyamine metabolism. These points are addressed by int- nationally recognized experts in their contributions to this book.
Editors and Affiliations
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Departments of Surgery and Pathology, University of Maryland School of Medicine and Baltimore Veterans Affairs Medical Center, Baltimore
Jian-Ying Wang
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The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore
Robert A. Casero
