Advances in Breast Cancer Management, 2nd edition

1. Front Matter

   Pages i-xi

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2. Managing Menopausal Problems

   • Melody A. Cobleigh

   Pages 1-23

3. Sentinel Lymphadenectomy In Node Negative Breast Cancer

   • Philip I. Haigh, Armando E. Giuliano

   Pages 25-37

4. Postmastectomy Radiotherapy

   • Abram Recht

   Pages 39-55

5. The Molecular and Cellular Biology of HER2/neu Gene Amplification/Overexpression and the Clinical Development of Herceptin (Trastuzumab) Therapy for Breast Cancer

   • Mark D. Pegram, Gottfried Konecny, Dennis J. Slamon

   Pages 57-75

6. High-Dose Chemotherapy for Breast Cancer

   • Yago Nieto, Elizabeth J. Shpall

   Pages 77-114

7. High Dose Therapy with Stem Cell Support for Breast Cancer: The Jury Is Still Out

   • Michael Crump, Kathleen Pritchard

   Pages 115-136

8. Preoperative Chemotherapy for Operable Breast Cancer

   • Eleftherios P. Mamounas, Bernard Fisher

   Pages 137-155

9. Overview of Randomized Trials of Systemic Adjuvant Therapy

   • Peter M. Ravdin

   Pages 157-181

10. Chemoprevention of Breast Cancer

    • Ruth M. O’Regan

    Pages 183-207

11. Back Matter

    Pages 209-211

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The optimal management of breast cancer patients relies on the expertise of a team of medical specialists including radiologists, surgeons, radiation therapists and medical oncologists. Much of the progress in breast cancer management made over the last several years reflects the translation of observations made in the laboratory to the clinic. Critically evaluating the impact of new treatment approaches relies on a commitment to well-designed clinical trials. In this volume, Advances in Breast Cancer Management, a renowned group of breast cancer experts have been asked to provide their perspective on management issues that directly effect patients on a day-to-day basis. Dr. Melody Cobleigh discusses the consequences of estrogen deprivation and the ways of ameliorating secondary symptoms and the potential long-term morbidity. Drs. Haigh and Guiliano review the sentinel lymph node biopsy technique including results from their extensive experience. Dr. Abram Recht places into perspective the potential benefit of post-mastectomy radiotherapy and reviews recent trials that address this issue. Dr. Dennis Slamon takes from us from the laboratory to the clinic in explaining the development of Herceptin as a paradigm for therapy targeted to specific molecular characteristics of breast cancer tumor cells. Drs. Nieto, Shpall, Crump and Pritchard offer different perspectives on the future of high-dose chemotherapy with stem cell transplantation as a treatment for breast cancer patients. Drs.

• biopsy
• breast cancer
• cancer
• cell
• chemotherapy
• clinical trial
• morbidity
• oncology
• radiotherapy
• stem cell
• stem cell transplantation
• transplantation
• tumor

• Breast Medical Oncology, Division of Hematology/Oncology, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Medical School, Chicago, USA

  William J. Gradishar

• Cancer Center, Department of Surgery, Emory University School of Medicine, Atlanta, USA

  William C. Wood

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