Biophysics of the Failing Heart

1. Front Matter

   Pages i-vi

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2. Introduction to the Biophysics of the Failing Heart

   • R. John Solaro, Jil C. Tardiff

   Pages 1-4

3. Sarcoplasmic Reticulum Ca Homeostasis and Heart Failure

   • Aleksey V. Zima, Dmitry Terentyev

   Pages 5-36

4. Ca-Homeostasis and Heart Failure: Focus on the Biophysics of Surface Membrane Ca-Fluxes

   • Kathrin Banach

   Pages 37-61

5. Biophysics of Membrane Currents in Heart Failure

   • Man Liu, Vikram Maddikunta Brahmanandam, Samuel C. Dudley Jr.

   Pages 63-90

6. Biophysical Mechanisms for the Metabolic Component of Impaired Heart Function

   • E. Douglas Lewandowski

   Pages 91-121

7. Cytoskeletal Nuclear Links in the Cardiomyocyte

   • Elizabeth McNally

   Pages 123-140

8. Biophysical Forces Modulate the Costamere and Z-Disc for Sarcomere Remodeling in Heart Failure

   • Allen M. Samarel, Yevgeniya Koshman, Erik R. Swanson, Brenda Russell

   Pages 141-174

9. Heart Failure: The Final Frontier for Biophysics in Cardiovascular Medicine?

   • Luis F. Santana

   Pages 175-181

10. Arrhythmogenesis, Heart Failure, and the Biophysics of Z-Band Protein Networks

    • M. Vatta, R. John Solaro

    Pages 183-199

11. Biophysics of Titin in Cardiac Health and Disease

    • Brian R. Anderson, Henk L. Granzier

    Pages 201-223

12. Sarcomeres and the Biophysics of Heart Failure

    • Jillian N. Simon, Jil C. Tardiff, Beata M. Wolska

    Pages 225-247

13. Back Matter

    Pages 249-253

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Subjects in the monograph “Biophysics of the Failing Heart” include state of the art chapters considering major biophysical mechanisms for why hearts responding to acquired or inherited stressors enter into maladaptive processes eventually leading to an inability of the heart to respond efficiently to hemodynamic loads especially during exercise. The chapters describe biophysical techniques that have been applied to determine the triggers for the heart failure process as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. By its emphasis on biophysical aspects of a prevalent clinical condition, the monograph is unique in its perspective and focus. The breadth of information in the chapters all in one place will be of value to clinicians and researchers at all levels. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. In most cases, combinations of clinician scientists and researchers author the chapters. A main benefit of the book is couched in its didactic approach together with its emphasis on how biophysical concepts and techniques aid in diagnosis and development of new therapies.

• Biophysics of Heart Failure
• Ca-homeostasis and Heart Failure
• Energy Metabolism in Heart Failure
• calcium homeostasis
• cardiac decompensation
• cardiac energetics
• excitation contraction coupling
• extra-cellular matrix

From the reviews:

“This is an up-to-date synthesis of the molecular and cellular biophysics of both normal and various cardiac pathologies with an emphasis on heart failure. … It is designed as a useful resource for cardiology practitioners and basic scientists looking for a current in-depth review of cardiac molecular biophysiology. … The book is extensively illustrated with diagrams and figures. This is a necessary addition to the literature addressing the biophysiology in the failing heart. It will be useful to cardiovascular specialists and basic scientists.” (Don A. Davis, Doody’s Book Reviews, January, 2014)

• Dept. of Physiology & Biophysics, University of Illinois at Chicago, Chicago, USA

  R. John Solaro

• University of Arizona, Tucson, USA

  Jil C. Tardiff

R. John Solaro is a Distinguished University Professor at the University of Illinois, Chicago and the head of the Physiology and Biophysics department.

Jil C. Tardiff is a Professor at the Department of Cellular and Molecular Medicine at the University of Arizona in Tucson. She is also a practicing cardiologist.

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