Overview
- An exciting overview of the advances in the genetics and biology of liver cancer, diagnosis, treatment and prevention
- Chapters range from genetics and environmental risk factors, genetics of liver development and pathogenesis, epigenetic changes associated with liver cancer, the utilities of genetic animal models, cancer stem cells, applying gene expression profiling by microarrays to liver cancer, to liver cancer genetics in the clinic
- Includes supplementary material: sn.pub/extras
Part of the book series: Cancer Genetics (CANGENETICS)
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Table of contents (20 chapters)
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Front Matter
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Liver Cancer Development and Pathogenesis
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Front Matter
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Liver Development And Pathogenesis
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Genetics and Epidemiology of Liver Cancer
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Front Matter
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Genetics And Epidemiology Of Liver Cancer
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Molecular Basis of Cancer Susceptibility
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Front Matter
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Molecular Basis Of Cancer Susceptibility
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Global Gene Expression Profiling of Human Liver Cancer
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Front Matter
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Global Gene Expression Profiling Of Human Liver Cancer
Keywords
About this book
Primary liver cancer is the third most deadly and fifth most common cancer worldwide (~500,000 deaths annually), with a sharp increase of incidence in the United States in recent years. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. Risk factors include gender, hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism diseases, diabetes, obesity, toxins, excess alcohol consumption and smoking. Liver cancer arises most frequently in inflammatory livers with extensive oxidative stress due to viral hepatitis which causes over 80% of HCC cases worldwide. Currently, survival remains dismal for most HCC and CC patients, largely due to the tumor’s aggressiveness at the time of diagnosis and the lack of effective therapy.
Editors and Affiliations
Bibliographic Information
Book Title: Molecular Genetics of Liver Neoplasia
Editors: Xin Wei Wang, Joe W. Grisham, Snorri S. Thorgeirsson
Series Title: Cancer Genetics
DOI: https://doi.org/10.1007/978-1-4419-6082-5
Publisher: Springer New York, NY
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media, LLC 2011
Hardcover ISBN: 978-1-4419-6081-8Published: 08 November 2010
Softcover ISBN: 978-1-4614-2731-5Published: 25 December 2012
eBook ISBN: 978-1-4419-6082-5Published: 08 November 2010
Series ISSN: 2626-1456
Series E-ISSN: 2626-1464
Edition Number: 1
Number of Pages: XIV, 399
Topics: Cancer Research, Pharmacology/Toxicology