Skip to main content
SpringerLink
Log in
Book cover

Acute Myelogenous Leukemia

Genetics, Biology and Therapy

  • Book
  • © 2010

Overview

Editors:
  1. Lalitha Nagarajan

    1. Dept. of Genetics, MD Anderson Cancer Center, Houston, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Contains chapters from pioneers in the area of genetic mechanisms, targeted therapy, biology and mouse models for acute myelogenous leukemia
  • Includes supplementary material: sn.pub/extras

Part of the book series: Cancer Treatment and Research (CTAR, volume 145)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (15 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. The Leukemia Stem Cell

    • Zeev Estrov
    Pages 1-17

  3. Epigenetic Mechanisms in AML – A Target for Therapy

    • Yasuhiro Oki, Jean - Pierre J. Issa
    Pages 19-40

  4. Chromosomal Translocations in AML: Detection and Prognostic Significance

    • Nallasivam Palanisamy
    Pages 41-58

  5. Chromosomal Deletions in AML

    • Lalitha Nagarajan
    Pages 59-66

  6. Genes Predictive of Outcome and Novel Molecular Classification Schemes in Adult Acute Myeloid Leukemia

    • Roel G. W. Verhaak, Peter J. M. Valk
    Pages 67-83

  7. Receptor Tyrosine Kinase Alterations in AML – Biology and Therapy

    • Derek L. Stirewalt, Soheil Meshinchi
    Pages 85-108

  8. Lineage-Specific Transcription Factor Aberrations in AML

    • Beatrice U. Mueller, Thomas Pabst
    Pages 109-125

  9. Proleukemic RUNX1 and CBFβ Mutations in the Pathogenesis of Acute Leukemia

    • Michael E. Engel, Scott W. Hiebert
    Pages 127-147

  10. Acute Myeloid Leukemia with Mutated Nucleophosmin (NPM1): Molecular, Pathological, and Clinical Features

    • Brunangelo Falini
    Pages 149-168

  11. MicroRNAs: New Players in AML Pathogenesis

    • Milena S. Nicoloso, Bharti Jasra, George A. Calin
    Pages 169-181

  12. Murine Models of Human Acute Myeloid Leukemia

    • Julie M. Fortier, Timothy A. Graubert
    Pages 183-196

  13. Apoptosis in Leukemias: Regulation and Therapeutic Targeting

    • Ismael Samudio, Marina Konopleva, Bing Carter, Michael Andreeff
    Pages 197-217

  14. Acute Promyelocytic Leukemia: A Paradigm for Differentiation Therapy

    • David Grimwade, Anita R. Mistry, Ellen Solomon, Fabien Guidez
    Pages 219-235

  15. Immunotherapy of AML

    • Gheath Alatrash, Jeffrey J. Molldrem
    Pages 237-255

  16. Therapy of Acute Myelogenous Leukemia in Adults

    • Gautam Borthakur, Elihu E. Estey
    Pages 257-271

  17. Back Matter

    Pages 273-280
    Download chapter PDF
Back to top

Keywords

About this book

Acute myelogenous leukemia (AML), is the most common form of leukemia in adults. AML is a deadly form of malignancy, the prognosis for which has not improved in the last two decades. More importantly, it is a malignancy that is seen in older adults, therefore the number of cases is likely to rise as the population ages. Over the past 15 years, genetic mechanisms underlying AML have begun to unfold. Additional research in this area has helped identify key components and characteristics. Consequently, targeted therapy of AML is receiving much attention. It is the hope of researchers that as with chronic myelogenous leukemia (CML), and the drug, Gleevec, a targeted therapy for AML will be discovered.

Editors and Affiliations

  • Dept. of Genetics, MD Anderson Cancer Center, Houston, USA

    Lalitha Nagarajan

About the editor

Lalitha Nagarajan is an Associate Professor, Department of Molecular Genetics, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas. 

Bibliographic Information

  • Book Title: Acute Myelogenous Leukemia

  • Book Subtitle: Genetics, Biology and Therapy

  • Editors: Lalitha Nagarajan

  • Series Title: Cancer Treatment and Research

  • DOI: https://doi.org/10.1007/978-0-387-69259-3

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag New York 2010

  • Hardcover ISBN: 978-0-387-69257-9Published: 18 November 2009

  • Softcover ISBN: 978-1-4419-1299-2Due: 02 December 2010

  • eBook ISBN: 978-0-387-69259-3Published: 20 March 2010

  • Series ISSN: 0927-3042

  • Series E-ISSN: 2509-8497

  • Edition Number: 1

  • Number of Pages: IX, 280

  • Topics: Oncology, Hematology, Systems Theory, Control

Publish with us

Policies and ethics

Back to top

Search

Navigation