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MR thermometry analysis program for laser- or high-intensity focused ultrasound (HIFU)-induced heating at a clinical MR scanner

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Abstract

Magnetic resonance (MR) thermometry is a noninvasive method for monitoring local temperature change during thermal therapy. In this study, a MR temperature analysis program was established for a laser with gold nanorods (GNRs) and high-intensity focused ultrasound (HIFU)-induced heating MR thermometry. The MR temperature map was reconstructed using the water proton resonance frequency (PRF) method. The temperature-sensitive phase difference was acquired by using complex number subtraction instead of direct phase subtraction in order to avoid another phase unwrapping process. A temperature map-analyzing program was developed and implemented in IDL (Interactive Data Language) for effective temperature monitoring. This one program was applied to two different heating devices at a clinical MR scanner. All images were acquired with the fast spoiled gradient echo (fSPGR) pulse sequence on a 3.0 T GE Discovery MR750 scanner with an 8-channel knee array coil or with a home-built small surface coil. The analyzed temperature values were confirmed by using values simultaneously measured with an optical temperature probe (R2 = 0.996). The temperature change in small samples induced by a laser or by HIFU was analyzed by using a raw data, that consisted of complex numbers. This study shows that our MR thermometry analysis program can be used for thermal therapy study with a laser or HIFU at a clinical MR scanner. It can also be applied to temperature monitoring for any other thermal therapy based on the PRF method.

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Authors and Affiliations

  1. Department of Radiology, Severance Hospital, YUHS-KRIBB Medical Convergence Research Institute, Yonsei University College of Medicine, Seoul, 120-752, Korea

    Eun Ju Kim, Kiyoung Jeong, Seung Jae Oh, Eun Hae Park, Young Han Lee & Jin-Suck Suh

  2. Molecular Imaging & Therapy Branch, National Cancer Center, Goyang, 410-769, Korea

    Daehong Kim

  3. Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, 120-752, Korea

    Eun Hae Park, Young Han Lee & Jin-Suck Suh

Authors
  1. Eun Ju Kim
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  2. Kiyoung Jeong
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  3. Seung Jae Oh
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  4. Daehong Kim
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  7. Jin-Suck Suh
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Correspondence to Jin-Suck Suh.

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Kim, E.J., Jeong, K., Oh, S.J. et al. MR thermometry analysis program for laser- or high-intensity focused ultrasound (HIFU)-induced heating at a clinical MR scanner. Journal of the Korean Physical Society 65, 2126–2131 (2014). https://doi.org/10.3938/jkps.65.2126

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  • DOI: https://doi.org/10.3938/jkps.65.2126

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