, Volume 10, Issue 2, pp 252-269

Pupil diameter tracks changes in control state predicted by the adaptive gain theory of locus coeruleus function

Abstract

An important dimension of cognitive control is the adaptive regulation of the balance between exploitation (pursuing known sources of reward) and exploration (seeking new ones) in response to changes in task utility. Recent studies have suggested that the locus coeruleus-norepinephrine system may play an important role in this function and that pupil diameter can be used to index locus coeruleus activity. On the basis of this, we reasoned that pupil diameter may correlate closely with control state and associated changes in behavior. Specifically, we predicted that increases in baseline pupil diameter would be associated with decreases in task utility and disengagement from the task (exploration), whereas reduced baseline diameter (but increases in task-evoked dilations) would be associated with task engagement (exploitation). Findings in three experiments were consistent with these predictions, suggesting that pupillometry may be useful as an index of both control state and, indirectly, locus coeruleus function.

This research was supported by the Netherlands Organization for Scientific Research (grant to S.N.), a National Institute of Mental Health Sylvio O. Conte Center Grant for Neuroscience Research (Grant MH062196 to M.S.G. and J.D.C.), and the Center for the Study of Brain, Mind, and Behavior at Princeton University.