Versatile computerized system for tracking and analysis of water maze tests
A crucial step in the estimation of properties of compounds in behavioral experiments is the quantification and description of the different effects observed. The goal of the present work was the automation of the Morris water maze test, one of the most popular behavioral methods for the study of animal memory. An original system was developed that provides fast and accurate tracking of animals, storage of the results in the database and video archive and a means of analyzing the results. This computerized version of the Morris water maze test permits the quantification of such vague characteristics of cognitive function as the “directionality” of search of the hidden platform after a standard training series. The suggestedparameters made it possible to discriminate cognitive properties of the novel compounds from other behavioral effects affecting escape latency. The effectiveness of this system was demonstrated in two experiments with neurochemically lesioned and drug-treated rats.
- Bachurin, S., Oxenkrug, G., Lermontova, N., Afanasiev, A, Beznosko, B., Vankin, G., Shevtzova, K, Mukhina, T., Serkova, T. (1999). N-Acetylserotonin, melatonin and their derivatives improve cognition and protect against β-amyloid-induced neurotixicity. In B. Trembly & W. Slikker, Jr. (Eds.), Neuroprotective agents: Fourth international conferences (Annals of the New York Academy of Sciences, Vol.890, pp. 155–166). New York: New York Academy of Sciences.
- Cain, D. P., Ighanian, K.,&Boon, F. (2000). Individual and combined manipulation of muscarinic, NMDA, and benzodiazepine receptor activity in the water maze task: Implications for a rat model of Alzheimer dementia.Behavioural Brain Research,111, 125–137. CrossRef
- Dalm, S., Grootendorst, J., de Kloet, E.R., &Oitzl, M.S. (2000). Quantification of swim patterns in the Morris water maze.Behavior Research Methods, Instruments, & Computers,32, 134–139.
- Eijkenboom, M., Gerlach, I., Jork, R, Lowe, D., &van der Staay, F. J. (2000). Effects of subdural haematoma on sensorimotor functioning and spatial learning in rats.Neuropharmacology,39, 817–834. CrossRef
- Fisher, A, &Hanin, I. (1986). Potential animal models for senile dementia of Alzheimer’s type with emphasis on AF64A-induced cholinotoxicity.Annual Reviews of Pharmacology & Toxicology,26, 161–181. CrossRef
- Grigoryan, G., Hodges, H., Mitchell, S., Sinden, J. D., &Gray, J. A. (1996). 6-OHDA lesions of the nucleus accumbens accentuate memory deficits in animals with lesions to the forebrain cholinergic projection system: Effects of nicotine administration on learning and memory in the water maze.Neurobiology of Learning & Memory,65, 135–153. CrossRef
- Lermontova, N. N., Lukoyanov, N. V., Serkova, T. P., Lukoyanova, E. A., &Bachurin, S. O. (1998). Effects of Tacrine on memory deficits in rats treated with cholinergic neurotoxin AF64A.Molecular & Chemical Neuropathology,33, 51–61. CrossRef
- Morris, R. C. M. (1981). Spatial localization does not require the presence of local cues.Learning & Motivation,12, 239–260. CrossRef
- Steele, R J., &Morris, R. G. M. (1999). Delay-dependent impairment of a matching-to-place task with chronic and intrahippocampal infusion of the NMDA-antagonist D-AP5.Hippocampus,9, 118–136. CrossRef
- Walsh, T., &Opello, K. (1994). The use of AF64A to model Alzheimer’s disease. In M. I. Woodruff & A. J. Nonneman (Eds.),Toxin-induced models of neurological disorders (pp. 259–279). New York: Plenum.
- Whishaw, L. Q., Cassel, J.-C., &Jarrard, L. E. (1995). Rats with fimbriafornix lesions display a place response in a swimming pool: A dissociation between getting there and knowing where.Journal of Neuroscience,15, 5779–5788.
- Versatile computerized system for tracking and analysis of water maze tests
Behavior Research Methods, Instruments, & Computers
Volume 33, Issue 3 , pp 371-380
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