, Volume 16, Issue 5, pp 377-383

Association between apolipoprotein E4 genotype and human immunodeficiency virus-associated dementia in younger adults starting antiretroviral therapy in South Africa

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It is not known whether the apolipoprotein E (ApoE) ε4 allelic variant is associated with human immunodeficiency virus (HIV)-associated dementia (HAD) in a South African population, where HIV clade C is predominant. ApoE genotyping was performed on 144 participants in a larger study of HIV-associated neurocognitive disorders (HAND). There was a lower frequency of the ε2 and ε3 alleles in the HIV-positive group, compared to a group of 300 community-based newborn infants. There were no differences in ApoE genotype across different categories of HAND. The ε4 allelic variant was less common in individuals with HAD than in those without HAD. These findings suggest that the ε4 allelic variant in HIV-positive individuals is not associated with the development of HAD in Southern Africa.

J.J. has received support from the National Research Foundation, the Biological Psychiatry Special Interest Group of the South Africa Society of Psychiatrists, the Medical Research Foundation of South Africa, and the Faculty of Health Sciences Research Committee, University of Cape Town. M.C. has received support from the National Research Foundation of South Africa. D.J.S. has received research grants and/or consultancy honoraria from Astrazeneca, Eli-Lilly, Glaxosmithkline, Lundbeck, Orion, Pfizer, Pharmacia, Roche, Servier, Solvay, Sumitomo, and Wyeth. The authors wish to thank the following research staff: Jean Luyt, Dr. Tricia Owen, Dorothy Magwaxaza, Lorraine Adendorff, and Judy Xala. The authors also thank the research participants for their time and willingness to take part.
This paper was first published online on Early Online on 8 September 2010.