, Volume 16, Issue 5, pp 405-409

Role of a cdk5-associated protein, p35, in herpes simplex virus type 1 replicationin vivo

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Previous studies have shown that herpes simplex virus type 1 (HSV-1) replication is inhibited by the cyclin-dependent kinase (cdk) inhibitor roscovitine. One roscovitine-sensitive cdk that functions in neurons is cdk5, which is activated in part by its binding partner, p35. Because HSV establishes latent infections in sensory neurons, we sought to determine the role p35 plays in HSV-1 replicationin vivo. For these studies, wild-type (wt) and p35-/- mice were infected with HSV-1 using the mouse ocular model of HSV latency and reactivation. The current results indicate that p35 is an important determinant of viral replicationin vivo.

Steve D. Haenchen and Jeff A. Utter contributed equally to this work.
This research was supported in part by an NFGRF grant (2302-072) from the University of Kansas Center for Research. The authors would like to thank Joshua Hilliard for technical assistance and members of the Davido lab for helpful suggestions related to this project.
This paper was first published online on Early Online on 14 September 2010.