Journal of NeuroVirology

, Volume 16, Issue 3, pp 203–207

Herpes simplex virus type 1 persists in the aged brain through hypothetical expression of accessory genes

Mini Review

DOI: 10.3109/13550281003739040

Cite this article as:
Mori, I. Journal of NeuroVirology (2010) 16: 203. doi:10.3109/13550281003739040


Herpes simplex virus type 1 persists in the brain of most aged individuals and may contribute to the pathogenesis of Alzheimer’s disease. The virus likely utilizes accessory genes for neural spread within the nervous system and herpes simplex virus type 1 may regulate various host responses through an array of accessory genes. This mini-review focuses on these viral accessory genes that may shed light on the potential mechanisms of this enigmatic phenomenon in the elderly brain.


accessory genesamyloid-βcentral nervous systemherpes simplex virus type 1host responsesneural transport

Copyright information

© Journal of NeuroVirology, Inc. 2010

Authors and Affiliations

  1. 1.Faculty of Health and NutritionShubun UniversityAichiJapan