Journal of NeuroVirology

, Volume 15, Issue 5, pp 380–389

Vitamin A deficiency and behavioral and motor deficits in the human immunodeficiency virus type 1 transgenic rat

  • Harry L. June
  • Andrew Rong Song Tzeng Yang
  • Joseph L. Bryant
  • Odell Jones
  • Walter Royal
Article

DOI: 10.3109/13550280903350200

Cite this article as:
June, H.L., Tzeng Yang, A.R.S., Bryant, J.L. et al. Journal of NeuroVirology (2009) 15: 380. doi:10.3109/13550280903350200
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Abstract

The human immunodeficiency virus type 1 (HIV-1) transgenic (Tg) rat model incorporates a noninfectious viral genome that is under similar regulatory control mechanisms in vivo as those that exist with natural infection in humans. Vitamin A (VA) deficiency in humans has been associated with progressive systemic HIV disease and with impaired cognition in rodent models. The effects on of VA deficiency on the development of behavioral abnormalities with HIV infection have not been previously described. In these studies, wild-type (Wt) and Tg rats maintained on either a normal (VA+) or a VA-deficient (VA−) diet were examined for activity in an open field (horizontal activity, total distance, vertical activity, and rearing) and on rotarod testing. On both open field and rotarod testing, the Tg rats performed worse than the Wt rats, with the most severe deficits noted in the TgVA− animals. Analysis of the specific effects of the presence of the HIV transgene and the diet on the performance on the open field tests showed a dominant effect from the transgene on all of the tests, with an effect from the diet on only the number of rearings. On rotarod testing, effects form both the diet and the transgene were observed at lower speeds, at the highest speeds, and on the accelerating rotarod. These studies therefore demonstrate that behavioral and motor abnormalities can be detected in this model and are likely due to similar mechanisms by which humans infected with HIV might develop cognitive-motor impairment in association with VA deficiency.

Keywords

HIV-1 transgenic rat vitamin A retinoids rotarod open field 

Copyright information

© Journal of NeuroVirology, Inc. 2009

Authors and Affiliations

  • Harry L. June
    • 3
    • 4
  • Andrew Rong Song Tzeng Yang
    • 3
  • Joseph L. Bryant
    • 5
  • Odell Jones
    • 5
  • Walter Royal
    • 1
    • 2
    • 6
  1. 1.Department of NeurologyThe University of Maryland School of MedicineBaltimoreUSA
  2. 2.Department of Anatomy and NeurobiologyThe University of Maryland School of MedicineBaltimoreUSA
  3. 3.Department of PsychiatryThe University of Maryland School of MedicineBaltimoreUSA
  4. 4.Department of Pharmacology and Experimental TherapeuticsThe University of Maryland School of MedicineBaltimoreUSA
  5. 5.Department of PathologyThe University of Maryland School of MedicineBaltimoreUSA
  6. 6.Department of Veterans AffairsBaltimoreUSA
  7. 7.BaltimoreUSA

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