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SOI nanowire transistor for detection of D-NFATc1 molecules

  • Fundamental Problems of Biosensorics on the Basis of Nanoheterostructures
  • Published:
Optoelectronics, Instrumentation and Data Processing Aims and scope

Abstract

Nanowire (NW) detection is one of the fast and highly sensitive methods. An NW biosensor based on silicon-on-insulator (SOI) structures are used in the reported study for real-time label-free biospecific detection of the NFATc1 (D-NFATc1) cancer marker. For this purpose, the SOI NWs are functionalized with NFATc1 aptamers used as macromolecular probes. It is demonstrated that such a biosensor can ensure a detection limits up to 10−15 M, which is comparable with the sensitivity ensured by an NW biosensor with immobilized antibodies used as macromolecular probes. The results of this study demonstrate that such approaches to the development of sensor elements for highly sensitive diagnostics of diseases are really promising.

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Authors and Affiliations

  1. Orekhovich Institute of Biomedical Chemistry, Russian Academy of Medical Sciences, ul. Pogodinskaya 10, Moscow, 119121, Russia

    Yu. D. Ivanov, T. O. Pleshakova, A. F. Kozlov, K. A. Mal’sagova, N. V. Krokhin, A. L. Kaisheva, I. D. Shumov & A. I. Archakov

  2. Rzhanov Institute of Semiconductor Physics, Siberian Branch, Russian Academy of Sciences, pr. Akademika Lavrent’eva 13, Novosibirsk, 630090, Russia

    V. P. Popov, O. V. Naumova, B. I. Fomin, D. A. Nasimov & A. L. Aseev

Authors
  1. Yu. D. Ivanov
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  2. T. O. Pleshakova
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  3. A. F. Kozlov
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  4. K. A. Mal’sagova
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  5. N. V. Krokhin
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  6. A. L. Kaisheva
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  7. I. D. Shumov
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  8. V. P. Popov
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  9. O. V. Naumova
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  10. B. I. Fomin
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  11. D. A. Nasimov
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  12. A. L. Aseev
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  13. A. I. Archakov
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Corresponding author

Correspondence to Yu. D. Ivanov.

Additional information

Original Russian Text © Yu.D. Ivanov, T.O. Pleshakova, A.F. Kozlov, K.A. Mal’sagova, N.V. Krokhin, A.L. Kaisheva, I.D. Shumov, V.P. Popov, O.V. Naumova, B.I. Fomin, D.A. Nasimov, A. L. Aseev, A.I. Archakov, 2013, published in Avtometriya, 2013, Vol. 49, No. 5, pp. 119–126.

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Ivanov, Y.D., Pleshakova, T.O., Kozlov, A.F. et al. SOI nanowire transistor for detection of D-NFATc1 molecules. Optoelectron.Instrument.Proc. 49, 520–525 (2013). https://doi.org/10.3103/S8756699013050142

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  • DOI: https://doi.org/10.3103/S8756699013050142

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