Hepatitis a virus: Structure-functional features of genome, molecular diagnostics, and cultivation

  • T. Yu. Bondarenko
  • V. A. Ternovoi
  • S. V. Netesov
Review

DOI: 10.3103/S0891416813030038

Cite this article as:
Bondarenko, T.Y., Ternovoi, V.A. & Netesov, S.V. Mol. Genet. Microbiol. Virol. (2013) 28: 99. doi:10.3103/S0891416813030038

Abstract

Recently published data on the following features of hepatitis A virus (HAV) are reviewed: structure-functional genome features, genotyping, clinical findings, and current means of diagnostics. The growing need to study the genetic diversity of HAV isolates and the search for its possible new antigenic variants are underlined. Results of cultivation of different HAV strains are considered and analyzed for possible application in creation and production of vaccines and diagnostic kits.

Keywords

hepatitis A virus RNA reverse transcription polymerase chain reaction—RT-PCR cell culture vaccine 

Copyright information

© Allerton Press, Inc. 2013

Authors and Affiliations

  • T. Yu. Bondarenko
    • 1
    • 2
  • V. A. Ternovoi
    • 1
    • 2
  • S. V. Netesov
    • 1
    • 2
  1. 1.Vector State Research Center of Virology and BiotechnologyKol’tsovo, Novosibirsk oblastRussia
  2. 2.Novosibirsk State UniversityNovosibirskRussia

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