Modern molecular biological methods of diagnosing and monitoring oncological diseases, based on the phenomenon of the humoral immune response to tumor-associated antigens

  • Yu. V. Shebzukhov
  • P. V. Belousov
  • S. V. Khlgatyan
  • A. Yu. Sazykin
  • D. V. Kuprash
  • S. A. Nedospasov
Article

DOI: 10.3103/S0891416807020012

Cite this article as:
Shebzukhov, Y.V., Belousov, P.V., Khlgatyan, S.V. et al. Mol. Genet. Microbiol. Virol. (2007) 22: 41. doi:10.3103/S0891416807020012
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Abstract

The humoral immune response to tumor-associated antigens in cancer patients can be used as the basis for diagnosing and monitoring the disease. Moreover, identification of the protein targets of such a response can serve as the basis for developing antigen-specific anticancer vaccines. This review discusses the main methods for identifying and studying tumor-associated antigens, recognized by serum antibodies, and also notes the problems facing researchers, which must be solved to introduce serologic antigen kits into the clinical diagnosis of cancer.

Copyright information

© Allerton Press, Inc. 2007

Authors and Affiliations

  • Yu. V. Shebzukhov
    • 1
  • P. V. Belousov
    • 1
  • S. V. Khlgatyan
    • 1
  • A. Yu. Sazykin
    • 1
  • D. V. Kuprash
    • 2
  • S. A. Nedospasov
    • 2
  1. 1.Department of Molecular Immunology, Belozerskii Institute of Physicochemical BiologyLomonosov Moscow State UniversityMoscowRussia
  2. 2.Laboratory of Molecular Immunology, Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscowRussia

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