Abstract
Objectives
For the purpose of evaluation of exhaled NO as an index of airway inflammation, we assessed changes in fractional exhaled NO (FeNO) across a work shift and its relationship with respiratory complaints.
Material and Methods
Chronic and work-aggravated respiratory complaints were assessed using a questionnaire in 89 male textile workers. FeNO and spirometry were performed before and after a work shift and all the changes were registered.
Results
A significant increase in FeNO after a work shift was observed. Post-shift FeNO was significantly higher among the subjects with chronic respiratory complaints. There was an obvious decrease in FVC, and FEV1 after a work shift; however, we couldn’t find a significant relationship between changes in respiratory parameters and concentration of inhalable dusts.
Conclusions
FeNO increase after a work shift along with pulmonary function decrement and higher post-shift FeNO among subjects with respiratory complaints makes across-shift FeNO a non-invasive test for assessment of airway hyper-responsiveness in textile workers.
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References
Forstater M. Implications of the global financial and economic crisis on the textile and clothing sector. In: Sectoral coverage of the global economic crisis 2009. Geneva: International Labour Organization; 2009.
Wang XR, Zhanget HX, Sun BX, Dai HL, Hang JQ, Eisen EA, et al., A 20-year follow-up study on chronic respiratory effects of exposure to cotton dust. Eur Respir J. 2005;26:881–886 http://dx.doi.org/10.1183/09031936.05.00125604.
Zuskin EE, Valić FF. Change in the respiratory response to coarse cotton dust over a ten-year period. Am Rev Respir Dis. 1975;112:417–442.
Schilling RS, Hughes JP, Dingwall-Fordyce I, Gilson JC. An epidemiological study of byssinosis among Lancashire cotton workers. Br J Ind Med. 1955;12:217–227.
Imbus H, Suh M. Byssinosis: A study of 10 133 textile workers. Arch Environ Health. 1973;26:183–191, http://dx.doi.org/10.1080/00039896.1973.10666253.
Schilling RSF. Byssinosis in cotton and other textile workers. Lancet. 1956;2:261–225, http://dx.doi.org/10.1016/S0140-6736(56)92077-3.
Bouhuys A, Shoenberg JB, Beck GJ, Schilling RSF. Epidemiology of chronic lung disease in a cotton mill community. Lung. 1977;154:167–186, http://dx.doi.org/10.1007/BF02713532.
Beck GJ, Schachter EN, Maunder LR, Schilling RS. A prospective study of chronic lung disease in cotton textile workers. Ann Intern Med. 1982;97:645–651, http://dx.doi.org/10.7326/0003-4819-97-5-645.
Glindmeyer HW, Lefante JJ, Jones RN, Rando RJ, Kader HA, Weill H. Exposure-related declines in the lung function of cotton textile workers. Relationship to current workplace standards. Am Rev Respir Dis. 1991;144:675–683, http://dx.doi.org/10.1164/ajrccm/144.3_Pt_1.675.
Bouhuys A, Zuskin E. Chronic respiratory disease in hemp workers. A follow-up study, 1967–1974. Ann Intern Med. 1976;84(4):398–405, http://dx.doi.org/10.7326/0003-4819-84-4-398.
Christiani D, Ye T, Zhang S, Wegman DH, Eisen EA, Ryan L, et al. Cotton dust and endotoxin exposure and long-term decline in lung function: Results of a longitudinal study. Am J Ind Med. 1999;35(4):321–331, http://dx.doi.org/10.1002/(SICI)1097-0274(199904)35:4%3C321::AID-AJIM1%3E3.0.CO;2-L.
Hudson RH, Kilburn KH, Halprin GM, McKenzie W. Granulocyte recruitment to airways exposed to endotoxin aerosols. Am Rev Respir Dis. 1977;115:89–95.
Cavagna G, Foa V, Vigliani EC. Effects in man and rabbits of inhalation of cotton dust or extracts and purified endotoxins. Br J Ind Med. 1969;26:314–321.
Michel O, Nagy AM, Schroeven M, Duchateau J, Nève J, Fondu P, et al. Dose-response relationship to inhaled endotoxin in normal subjects. Am J Respir Crit Care Med. 1997;156(4):1157–1164, http://dx.doi.org/10.1164/ajrccm.156.4.97-02002.
Merchant JA, Lumsden JC, Kilburn KH, O’Fallon WM, Ujda JR, Germino VH, et al. Dose response studies in cotton textile workers. J Occup Med. 1973;15:222–230.
Rylander R, Imbus HR, Suh MW. Bacterial contamination of cotton as an indicator of respiratory effects among card room workers. Br J Ind Med. 1979;36:299–304.
Quirce S, Lemière C, de Blay F, del Pozo V, Gerth van Wijk R, Maestrelli P, et al. Noninvasive methods for assessment of airway inflammation in occupational settings. Allergy. 2010;65: 445–458, http://dx.doi.org/10.1111/j.1398-9995.2009.02274.x.
Alving K, Weitzberg E, Lundberg JM. Increased amount of nitric oxide in exhaled air of asthmatics. Eur Respir J. 1993;6:1368–1370.
Kharitonov SA, Yates D, Robbins RA, Logan-Sinclair R, Shinebourne EA, Barnes PJ. Increased nitric oxide in exhaled air of asthmatic patients. Lancet. 1994;343:133–135, http://dx.doi.org/10.1016/S0140-6736(94)90931-8.
Kharitonov SA, Yates D, Springall DR, Buttery L, Polak J, Robbins RA, et al. Exhaled nitric oxide is increased in asthma. Chest. 1995;107(3 Suppl):156–17S, http://dx.doi.org/10.1378/chest.107.3_Supplement.156S.
Massaro AF, Gaston B, Kita D, Fanta C, Stamler JS, Drazen JM. Expired nitric oxide levels during treatment of acute asthma. Am J Respir Crit Care Med. 1995;152:800–803, http://dx.doi.org/10.1164/ajrccm.152.2.7633745.
Persson MG, Zetterstrom O, Agrenius V, Ihre E, Gustafsson L. Single breath nitric oxide measurements in asthmatic patients and smokers. Lancet. 1994;343:146–147, http://dx.doi.org/10.1016/S0140-6736(94)90935-0.
Lund MB, Oksnel PI, Hamre R, Kongerud J. Increased nitric oxide in exhaled air: An early marker of asthma in non-smoking aluminium potroom workers? Occup Environ Med. 2000;57:274–278, http://dx.doi.org/10.1136/oem.57.4.274.
Świerczyńska-Machura D, Krakowiak A, Wiszniewska M, Dudek W, Walusiak J, Pałczyński C. Exhaled nitric oxide levels after specific inahalatory challenge test in subjects with diagnosed occupational asthma. Int J Occup Med Environ Health. 2008;21:219–225, http://dx.doi.org/10.2478/v10001-008-0024-x.
Piipari R, Piirila P, Keskinen H, Tuppurainen M, Sovijarvi A, Nordman H. Exhaled nitric oxide in specific challenge tests to assess occupational asthma. Eur Respir J. 2002;20:1532–1537, http://dx.doi.org/10.1183/09031936.02.00041802.
Barbinova L, Baur X. Increase in exhaled nitric oxide (eNO) after work-related isocyanate exposure. Int Arch Occup Environ Health. 2006;79:387–385, http://dx.doi.org/10.1007/s00420-005-0051-x.
American Thoracic Society. Modified recommended respiratory disease questionnaires for use with adults and children in epidemiological research. Washington DC: American Thoracic Society; 1978. Available from: http://www.thoracic.org/statements/resources/archive/rrdquacer.pdf.
American Thoracic Society. ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide. Am J Respir Crit Care Med. 2005;171:912–930, http://dx.doi.org/10.1164/rccm.200406-710ST.
American Thoracic Society. An official ATS clinical practice guideline: Interpretation of exhaled nitric oxide levels (FeNO) for clinical applications. Am J Respir Crit Care Med. 2011;184:602–615, http://dx.doi.org/10.1164/rccm.9120-11ST.
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J. 2005;26(2):319–338, http://dx.doi.org/10.1183/09031936.05.00034805.
Occupational Safety and Health Administration. Occupational safety and health standards: Toxic and hazardous substances. Cotton dust [cited 2010 Sept 24]. Available from: https://www.osha.gov/pls/oshaweb/owadisp.show_document?p_table=STANDARDS&p_id=10053.
Mandryk J, Alwis KU, Hocking AD. Work-related symptoms and dose-response relationships for personal exposures and pulmonary function among woodworkers. Am J Ind Med. 1999;35:481–490, http://dx.doi.org/10.1002/(SICI)1097-0274(199905)35:5%3C481::AID-AJIM5%3E3.0.CO;2-N.
Sepulveda MJ, Castellan RM, Hankinson JL, Cocke JB. Acute lung function response to cotton dust in atopic and non-atopic individuals. Br J Ind Med. 1984;41:487–491.
Sandstrom T, Bjermer L, Rylander R. Lipopolysaccharide (LPS) inhalation in healthy subjects increases neutrophils, lymphocytes and fibronectin levels in bronchoalveolar lavage fluid. Eur Respir J. 1992;5(8):992–926.
Heldal KK, Madsø L, Huser PO, Eduard W. Exposure, symptoms and airway inflammation among sewage workers. Ann Agric Environ Med. 2010;17:263–268.
Baur X, Barbinova L. Latex allergen exposure increases exhaled nitric oxide in symptomatic healthcare workers. Eur Respir J. 2005;25:309–316, http://dx.doi.org/10.1183/09031936.05.00021504.
Moen BE, Sakwari G, Mamuya SH, Kayumba AV, Larsson L, Pehrson C, et al. Respiratory inflammation among workers exposed to airborne dust with endotoxins in a coffee curing factory 2012. J Occup Environ Med. 2012;54:847–85
Sakwari G, Mamuya S, Bratveit M, Moen BE. Respiratory symptoms, exhaled nitric oxide, and lung function among workers in Tanzanian coffee factories. J Occup Environ Med. 2013;55:544–551, http://dx.doi.org/10.1097/JOM.0b013e318285f453.
Mattes J, van’s Gravesande KS, Moeller C, Moseler M, Brandis M, Kuehr J. Circadian variation of exhaled nitric oxide and urinary eosinophil protein X in asthmatic and healthy children. Pediatr Res. 2002;51(2):190–194, http://dx.doi.org/10.1203/00006450-200202000-00011.
Antosova M, Bencova A, Psenkova A, Herle D, Rozborilova E. Exhaled nitric oxide-circadian variations in healthy subjects. Eur J Med Res. 2009;14(Suppl 4):6.
Georges G, Bartelson BB, Martin RJ, Silkoff PE. Circadian variation in exhaled nitric oxide in nocturnal asthma. J Asthma. 1999;36:467–473, http://dx.doi.org/10.3109/02770909909087289.
ten Hacken NH, van der Vaart H, van der Mark TW, Koeter GH, Postma DS. Exhaled nitric oxide is higher both at day and night in subjects with nocturnal asthma. Am J Respir Crit Care Med. 1998;158:902–907, http://dx.doi.org/10.1164/ajrccm.158.3.9712021.
Olin AC, Alving K, Toren K. Exhaled nitric oxide: Relation to sensitization and respiratory symptoms. Clin Exp Allergy. 2004;34:221–226, http://dx.doi.org/10.1111/j.1365-2222.2004.01888.x.
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Mirmohammadi, S.J., Mehrparvar, A.H., Safaei, S. et al. Across-shift changes of exhaled nitric oxide and spirometric indices among cotton textile workers. IJOMEH 27, 707–715 (2014). https://doi.org/10.2478/s13382-014-0306-4
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DOI: https://doi.org/10.2478/s13382-014-0306-4