Translational Neuroscience

, Volume 3, Issue 4, pp 334–344

Homeostatic function of astrocytes: Ca2+ and Na+ signalling

Review Article

DOI: 10.2478/s13380-012-0040-y

Cite this article as:
Parpura, V. & Verkhratsky, A. Translat.Neurosci. (2012) 3: 334. doi:10.2478/s13380-012-0040-y
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Abstract

The name astroglia unifies many non-excitable neural cells that act as primary homeostatic cells in the nervous system. Neuronal activity triggers multiple homeostatic responses of astroglia that include increase in metabolic activity and synthesis of neuronal preferred energy substrate lactate, clearance of neurotransmitters and buffering of extracellular K+ ions to name but a few. Many (if not all) of astroglial homeostatic responses are controlled by dynamic changes in the cytoplasmic concentration of two cations, Ca2+ and Na+. Intracellular concentration of these ions is tightly controlled by several transporters and can be rapidly affected by the activation of respective fluxes through ionic channels or ion exchangers. Here, we provide a comprehensive review of astroglial Ca2+ and Na+ signalling.

Keywords

AstrocyteHomeostasisExcitabilityCa2+ signallingNa+ signalling

Abbreviations

AMPA

α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid

[Ca2+]i

cytoplasmic free Ca2+ concentration

[Ca2+]L

intra-ER (or intraluminal) free Ca2+ concentration

CNS

central nervous system

CRAC

Ca2+-release activated Ca2+

ER

endoplasmic reticulum

GABA

γ-aminobutyric acid

InsP3R

inositol 1,4,5 trisphosphate (InsP3)-gated Ca2+ channel/receptor

[Na+]i

cytoplasmic Na+ concentration

NCX

Na+/Ca2+ exchanger

NKA

Na+/K+ ATPase

NMDA

N-methyl D-aspartate

PLC

phospholipase C

PMCA

plasmalemmal Ca2+ ATPase

RyR

ryanodine receptor

SERCA

sarco(endoplasmic) reticulum Ca2+ ATPase

SLC

solute carrier

TRP

transient receptor potential

Copyright information

© Versita Warsaw and Springer-Verlag Wien 2012

Authors and Affiliations

  1. 1.Department of Neurobiology, Center for Glial Biology in Medicine, Atomic Force Microscopy & Nanotechnology Laboratories, Civitan International Research Center, Evelyn F. McKnight Brain InstituteUniversity of AlabamaBirminghamUSA
  2. 2.Department of BiotechnologyUniversity of RijekaRijekaCroatia
  3. 3.IKERBASQUEBasque Foundation for ScienceBilbaoSpain
  4. 4.Department of NeurosciencesUniversity of the Basque Country UPV/EHULeioaSpain
  5. 5.Faculty of Life SciencesThe University of ManchesterManchesterUK