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Prevalence of Legionella antibodies in immunocompromised patients

  • Research Article
  • Published:
Central European Journal of Medicine

Abstract

Introduction

Dialysis patients and patients post-renal transplantation can be predisposed to Legionella infections. The aim of this work was to investigate the prevalence of L. pneumophila serogroups 1–7 (SG 1–7) antibodies in dialysis patients and in patients following renal transplantation, in order to analyse the potential risk factors for infections.

Material and Methods

Commercial ELISA kits were used for detection of serum IgG (SG 1–7, SG 1) and IgM (SG 1–7) present in patients and the control group. Results: In the studied group of patients, positive results (IgM and/or IgG SG 1–7) were obtained in 20 patients (7.12%). One patient only had two classes of antibodies. From the total study group, the antibodies against L. pneumophila SG 1 were detected in only one patient on dialysis. Patients with L. pneumophila antibodies who are on dialysis or post-renal transplantation did not differ significantly in any of the usually evaluated risk factors of clinical infection.

Conclusions

The reported outbreaks of Legionnaires’ disease in chronic dialysis patients and those with renal transplants, as well as our results of IgG and IgM antibodies, merit further identification of the sources of this infection but also the ways in which cellular immune system can be managed in the immunocompromised patients with Legionella infection.

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References

  1. Nichol K.L., Parenti C.M., Jonhson J.E. High prevalence of positive antibodies to Legionella pneumophila among outpatients, Chest, 1991, 100(3):663–666

    Article  PubMed  CAS  Google Scholar 

  2. Friedman H., Yamamoto Y., Klein T.W. Legionella pneumophila pathogenesis and immunity, Semin. Pediatr. Infect. Dis., 2002, 13(4):273–279

    Article  PubMed  Google Scholar 

  3. Diederen B.M.W. Legionella spp. and legionnaires’disease, J Infect, 2008, 56(1):1–12

    Article  PubMed  CAS  Google Scholar 

  4. Javed S., Chaudhry R., Passi K., Sharma S., Dhawan B., Dey A.B. Sero diagnosis of Legionella infection in community acquired pneumonia, Indian J. Med. Res., 2010, 131:92–96

    PubMed  Google Scholar 

  5. Fields B.S., Benson F., Besser R.E. Legionella nad legionnaires’disease: 25 years of investigation, Clin. Microbiol. Rev., 2002, 15(3):506–526

    Article  PubMed  Google Scholar 

  6. Shimizu Y., Nagase K., Kadono K.N., Funayama Y., Tsurushima Y., Hibino T., et al. The haemodialysis patient who developed acute respiratory distress syndrome after a trip to a hot spring spa, Nephrol. Dial. Transplant., 1999, 14(2):455–457

    Article  PubMed  CAS  Google Scholar 

  7. Ongut G., Yavuz A., Ogunc D., Tuncer M., Ozturk F., Mutlu D., et al. Seroprevalence of antibodies to Legionella pneumophila on hemodialysis patients, Transplant. Proc., 2004, 36(1):44–46

    Article  PubMed  CAS  Google Scholar 

  8. Matuszewska R., Krogulska B. Problem występowania pałeczek Legionella w instalacjach i urządzeniach wytwarzających aerozol wodnopowietrzny w obiektach służby zdrowia w Polsce, Nowa Med., 2009, 1:56–60

    Google Scholar 

  9. Friedman H., Yamamoto Y., Newton C., Klein T. Immunologic response and pathophysiology of Legionella infection, Semin. Respir. Infect., 1998, 13(2):100–108

    PubMed  CAS  Google Scholar 

  10. Lettinga K.D., Verbon A., Weverling J.G., Schellekens FP, Den Boer J.W., Yzerman P.F., et al. Legionnaires’disease at a dutch flower show: prognostic factors and impact of therapy, Emerg. Infect. Dis., 2002, 8(12):1448–1454

    Article  PubMed  Google Scholar 

  11. Ampel N.M., Wing E.J. Legionella infection in transplant patients, Semin. Respir. Infect., 1990, 5(1):30–37

    PubMed  CAS  Google Scholar 

  12. Berman S.J. Infections in patients with end-stage renal disease: an overview, Infect. Dis. Clin. North. Am., 2001, 15(3):709–720

    Article  PubMed  CAS  Google Scholar 

  13. Chow J.W. Legionella: a major opportunictic pathogen in transplant recipients. Semin. Respir. Infect., 1998, 13(2):132–139.

    PubMed  CAS  Google Scholar 

  14. Foley R.N. Infections in patients with chronic kidney disease, Infect. Dis. Clin. North. Am., 2007, 21(3):659–672

    Article  PubMed  Google Scholar 

  15. Girndt M., Sester M., Sester U., Kaul H., Kohler H. Molecular aspects of T- and B-cell function in uremia, Kidney Int. Suppl., 2001, 78:S206–211

    PubMed  CAS  Google Scholar 

  16. Minnaganti V.R., Cunha BA. Infections associated with uremia and dialysis, Infect. Dis. Clin. North. Am., 2001, 15(2):385–306

    Article  PubMed  CAS  Google Scholar 

  17. Boldur I., Modai D., Iaine A., Boner G., Sompolinsky D. Legionnaires’disease in Israel: a serological study of hemodialysis patients, Isr. J. Med. Sci., 1982, 18(6):667–670

    PubMed  CAS  Google Scholar 

  18. Pesanti E.L. Immunologic defects and vaccination in patients with renal failure, Infect. Dis. Clin. North. Am. 2001, 15(3):813–832

    Article  PubMed  CAS  Google Scholar 

  19. Kool J.L., Fiore A.E., Kioski C.M., Brown E.W., Benson R.F., Pruckler J.M., et al. More than 10 years of unrecognized nosocomial transmission of legionnaires’disease among transplant patients, Infect. Control Hosp. Epidemiol., 1998, 19(12):898–904

    Article  PubMed  CAS  Google Scholar 

  20. Marshall W., Foster R.S., Winn W. Legionnaires’disease in renal transplant patients, Am. J. Surg., 1981, 141(4):423–429

    Article  PubMed  CAS  Google Scholar 

  21. Mazierii N.A., Godoy C.V., Alves S.F., Andrade D.R., Levin A.S., Hablitzel A.C. Legionnaires’disease in the renal transplant unit of “Hospital das Clinicas, FMUSP”, During a five year period (1988–1993), Rev. Inst. Med. Trop. Sao Paulo 1994, 36(3):231–236

    Article  Google Scholar 

  22. Morimoto T. Serum antibodies to Legionella pneumohila by indirect immunofluorescent antibody test in 269 hemodialysis patients and 353 healthy subjects, Rinsho Byori., 1991, 39(1):71–75

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Microbiology, Medical University of Lublin, Chodźki 1, 20-093, Lublin, Poland

    Agnieszka Sikora, Maria Kozioł-Montewka, Jolanta Paluch-Oleś & Agnieszka Magryś

  2. Department of Nephrology, Medical University of Lublin, Jaczewskiego 8, 20-090, Lublin, Poland

    Andrzej Książek, Agnieszka Grzebalska, Anna Bednarek-Skublewska & Anna Steć

  3. I Chair and Department of General and Transplant Surgery and Nutritional Treatment, Medical University of Lublin, Jaczewskiego 8, 20-090, Lublin, Poland

    Sławomir Rudzki & Jacek Furmaga

  4. Department of Genetics and Microbiology, Maria Curie-Skłodowska University, Akademicka 19, 20-033, Lublin, Poland

    Magdalena Karaś

Authors
  1. Agnieszka Sikora
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  2. Maria Kozioł-Montewka
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  6. Anna Steć
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  7. Sławomir Rudzki
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  8. Jacek Furmaga
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  9. Jolanta Paluch-Oleś
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  10. Agnieszka Magryś
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  11. Magdalena Karaś
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Correspondence to Agnieszka Sikora.

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Sikora, A., Kozioł-Montewka, M., Książek, A. et al. Prevalence of Legionella antibodies in immunocompromised patients. cent.eur.j.med 8, 208–212 (2013). https://doi.org/10.2478/s11536-012-0120-y

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  • DOI: https://doi.org/10.2478/s11536-012-0120-y

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