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Reaction of barbituric acid with organic azides and phosphonium ylides

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Central European Journal of Chemistry

Abstract

Amination by organic azides has been carried out to provide aminobarbiturates by fusion of a triazole ring to the 5,6-positions of barbituric acid followed by cleavage and thermal elimination of nitrogen, whereas aza-Wittig reaction gave phosphoranylidene barbituric acid salts.

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Authors and Affiliations

  1. Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL, 32611-7200, USA

    Iryna O. Lebedyeva, Sean M. Sileno, Kunal Patel & Alan R. Katritzky

  2. Department of Chemistry, University of Florida, PO box 117200, Gainesville, FL, 32611, USA

    Ion Ghiviriga

  3. Chemistry Department, University of Canterbury, Christchurch, 8140, New Zealand

    Peter J. Steel

  4. Chemistry Department, King Abdulaziz University, Jeddah, 21589, Saudi Arabia

    Alan R. Katritzky

Authors
  1. Iryna O. Lebedyeva
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  2. Sean M. Sileno
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  3. Kunal Patel
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  4. Ion Ghiviriga
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  5. Peter J. Steel
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  6. Alan R. Katritzky
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Corresponding author

Correspondence to Alan R. Katritzky.

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Lebedyeva, I.O., Sileno, S.M., Patel, K. et al. Reaction of barbituric acid with organic azides and phosphonium ylides. cent.eur.j.chem. 11, 1019–1022 (2013). https://doi.org/10.2478/s11532-013-0233-4

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  • DOI: https://doi.org/10.2478/s11532-013-0233-4

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