Translational Neuroscience

, Volume 4, Issue 1, pp 81-87

First online:

Reassessment of teratogenic risk from antenatal ultrasound

  • Emily L. WilliamsAffiliated withDepartment of Anatomical Sciences and Neurobiology, University of Louisville School of Medicine
  • , Manuel F. CasanovaAffiliated withDepartment of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine Email author 

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Science has shown that risk of cavitation and hyperthermia following prenatal ultrasound exposure is relatively negligible provided intensity, frequency, duration of exposure, and total numbers of exposures are safely limited. However, noncavitational mechanisms have been poorly studied and occur within what are currently considered “safe” levels of exposure. To date, the teratogenic capacity of noncavitational effectors are largely unknown, although studies have shown that different forms of ultrasound-induced hydraulic forces and pressures can alter membrane fluidity, proliferation, and expression of inflammatory and repair markers. Loose regulations, poor end user training, and unreliable ultrasound equipment may also increase the likelihood of cavitation and hyperthermia during prenatal exposure with prolonged durations and increased intensities. The literature suggests a need for tighter regulations on the use of ultrasound and further studies into its teratogenicity.


Cavitation Microstreaming Sonoporation Teratogens Ultrasonography Prenatal