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Neurogenic neuroprotection: Future perspectives

  • Review Article
  • Published:
Translational Neuroscience

Abstract

Introduction

Neurogenic neuroprotection elicited by deep brain stimulation is emerging as a promising approach for treating patients with ischemic brain lesions. In rats, stimulation of the fastigial nucleus, but not dentate nucleus, has been shown to reduce the volume of focal infarction. Protection of neural tissue is a rapid intervention that has a relatively long-lasting effect, rendering fastigial nucleus stimulation (FNS) a potentially valuable method for clinical application.

Methods

We review some of the main findings of animal experimental research from a clinical perspective. Results: Although the complete mechanisms of neuroprotection induced by FNS remain unclear, important data has been presented in the last two decades. The acute effect of electrical stimulation of the fastigial nucleus is likely mediated by a prolonged opening of potassium channels, and the sustained effect appears to be linked to inhibition of the apoptotic cascade.

Conclusion

A better understanding of the cellular and molecular mechanisms underlying neurogenic neuroprotection by stimulation of deep brain nuclei, with special attention to the fastigial nucleus, can contribute toward improving neurological outcomes in ischemic brain insults.

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Authors and Affiliations

  1. Department Of Neurology, University Of Sao Paulo School Of Medicine, São Paulo, Brazil

    Mauricio Mandel, Erich Talamoni Fonoff, Edson Bor-Seng-Shu & Manoel Jacobsen Teixeira

  2. Neuroregeneration Center, Experimental Neurology, Department of Neurology, University of São Paulo School of Medicine, São Paulo, Brasil

    Gerson Chadi

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  1. Mauricio Mandel
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  2. Erich Talamoni Fonoff
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Correspondence to Mauricio Mandel.

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Mandel, M., Fonoff, E.T., Bor-Seng-Shu, E. et al. Neurogenic neuroprotection: Future perspectives. Translat.Neurosci. 3, 399–412 (2012). https://doi.org/10.2478/s13380-012-0047-4

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