Original Paper

Chemical Papers

, Volume 67, Issue 4, pp 444-455

First online:

An efficient method for the preparation of benzyl γ-ketohexanoates

  • Muhammad IqbalAffiliated withDepartment of Chemistry, Gomal University Email author 
  • , Imam B. BalochAffiliated withDepartment of Chemistry, Gomal University
  • , Musa K. BalochAffiliated withDepartment of Chemistry, Gomal University

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Twenty acid chlorides, 4-(mono/di-benzyloxy)-4-ketobutanoyl chlorides (Ia–XXa) were synthesised by the reaction of monoesters of succinic acid with thionyl chloride. The product thus obtained (4-benzyloxy-4-ketobutanoyl chlorides) was treated with diethylcadmium to convert it into the corresponding keto-esters (Ib–XXb), the mono/di-benzyl-γ-ketohexanoates, with a good yield. All the compounds thus prepared were characterised by physical, spectroscopic (UV-VIS, IR, 1H NMR, 13C NMR), and mass measurements techniques.


γ-ketoesters mono/disubstituted-benzyl alcohols diethylcadmium monoesters of succinic acid