Chemical Papers

, Volume 67, Issue 4, pp 444–455

An efficient method for the preparation of benzyl γ-ketohexanoates

Original Paper

DOI: 10.2478/s11696-012-0282-8

Cite this article as:
Iqbal, M., Baloch, I.B. & Baloch, M.K. Chem. Pap. (2013) 67: 444. doi:10.2478/s11696-012-0282-8


Twenty acid chlorides, 4-(mono/di-benzyloxy)-4-ketobutanoyl chlorides (Ia–XXa) were synthesised by the reaction of monoesters of succinic acid with thionyl chloride. The product thus obtained (4-benzyloxy-4-ketobutanoyl chlorides) was treated with diethylcadmium to convert it into the corresponding keto-esters (Ib–XXb), the mono/di-benzyl-γ-ketohexanoates, with a good yield. All the compounds thus prepared were characterised by physical, spectroscopic (UV-VIS, IR, 1H NMR, 13C NMR), and mass measurements techniques.


γ-ketoestersmono/disubstituted-benzyl alcoholsdiethylcadmiummonoesters of succinic acid

Copyright information

© Institute of Chemistry, Slovak Academy of Sciences 2012

Authors and Affiliations

  • Muhammad Iqbal
    • 1
  • Imam B. Baloch
    • 1
  • Musa K. Baloch
    • 1
  1. 1.Department of ChemistryGomal UniversityDera Ismail KhanPakistan