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Synthesis of new antimicrobial 4-aminosubstituted 3-nitrocoumarins

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Abstract

A series of new coumarin derivatives has been synthesized by condensation of 4-chloro-3-nitrocoumarin and the appropriate arylamine and sulfonamide in ethyl acetate in the presence of triethylamine. The synthesized compounds were screened for their in vitro antimicrobial activity against thirteen strains of bacteria and three fungal/yeast strains using disk diffusion assays. They were shown to possess a wide range of activities from almost completely inactive compounds to medium active ones. (4-[(5-Chloropyridin-2-yl)amino]-3-nitro-2H-chromen-2-one) showed similar activity against Klebsiella pneumoniae as tetracycline.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science and Mathematics, University of Priština, Lole Ribara 29, 38220, Kosovska Mitrovica, Serbia

    Biljana Dekić & Vidoslav Dekić

  2. Department of Chemistry, Faculty of Science and Mathematics, University of Niš, Višegradska 33, 18000, Niš, Serbia

    Niko Radulović & Radosav Palić

  3. Department of Chemistry, Faculty of Science, University of Kragujevac, R. Domanovica 12, 34000, Kragujevac, Serbia

    Rastko Vukićević

Authors
  1. Biljana Dekić
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  2. Vidoslav Dekić
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  3. Niko Radulović
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  4. Rastko Vukićević
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  5. Radosav Palić
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Correspondence to Niko Radulović.

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Dekić, B., Dekić, V., Radulović, N. et al. Synthesis of new antimicrobial 4-aminosubstituted 3-nitrocoumarins. Chem. Pap. 64, 354–359 (2010). https://doi.org/10.2478/s11696-010-0004-z

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  • DOI: https://doi.org/10.2478/s11696-010-0004-z

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