, Volume 8, Issue 5, pp 600-607
Date: 05 Apr 2013

Validation of videodensitometric myocardial perfusion assessment

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Abstract

Introduction

Invasive methods for assessment of coronary microcirculatory function are time- and instrumentation-consuming tools. Recently, novel computer-assisted videodensitometric methods have been demonstrated to provide quantitative information on myocardial (re)perfusion. The aim of the present prospective study was to evaluate the accuracy of videodensitometry-derived perfusion parameters in patients with stable angina undergoing elective coronary angiography.

Methods

The study comprised 13 patients with borderline epicardial coronary artery stenosis (40–70%). Coronary flow reserve and index of microcirculatory resistance were measured by using an intracoronary pressure and temperature sensor-tipped guidewire. A videodensitometric quantitative parameter of myocardial perfusion was calculated by the ratio of maximal density (Gmax) and the time to reach maximum density (Tmax) of the time-density curves in regions of interest on conventional coronary angiograms. Myocardium perfusion reserve was calculated as a ratio of hyperemic and baseline Gmax/Tmax.

Results

At hyperemia a significant increase in Gmax/Tmax could be observed (p <0.0001). Significant correlations were found between myocardium perfusion reserve and coronary flow reserve (r =0.82, p =0.0008) and between hyperemic Gmax/Tmax and hyperemic index of microcirculatory resistance (r =−0.72, p =0.0058).

Conclusions

Videodensitometric Gmax/Tmax assessment seems to be a promising method to assess the myocardial microcirculatory state.