Research Article

Central European Journal of Medicine

, Volume 6, Issue 2, pp 158-162

First online:

Serum IGF-1 and IGFBP-3 levels in subclinical hypothyroid women

  • Huriye BalciAffiliated withFikret Biyal Central Research Laboratory, Cerrahpasa Medical Faculty, Istanbul University Email author 
  • , Tijen Yesim ErdemAffiliated withDivision of Endocrinology-Metabolism and Diabetes and Department of Medicine, Haseki Education and Research Hospital
  • , Serdal UgurluAffiliated withDivision of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University
  • , Demet Ozgul YetkinAffiliated withDivision of Endocrinology-Metabolism and Diabetes and Department of Medicine, Goztepe Education and Research Hospital
  • , I. Murat BolayirliAffiliated withFikret Biyal Central Research Laboratory, Cerrahpasa Medical Faculty, Istanbul University
  • , Munire HacibekirogluAffiliated withFikret Biyal Central Research Laboratory, Cerrahpasa Medical Faculty, Istanbul University
  • , Ertugrul TasanAffiliated withDivision of Endocrinology-Metabolism and Diabetes and Department of Medicine, Cerrahpasa Medical Faculty, Istanbul University

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Abstract

Thyroid status is known to influence growth in mammals. The aim of this study is to investigate the possible relationship between autoimmune subclinical hypothyroidism and growth hormone (GH), insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-3(IGFBP-3) levels. Thirty-five women with autoimmune subclinical hypothyroidism, 33 years of age, were used as controls and enrolled in the study. Free triiodothyronin (FT3), free thyroxin(FT4), thyrotropin(TSH), anti-thyroid peroxidase(Anti-TPO), anti-thyroglobuline(Anti-Tg), GH, IGF-1 and IGFBP-3 levels were measured in blood samples and correlations among these parameters were evaluated. We found no significant differences in GH, IGF-1 or IGFBP-3 between patients and controls. In patients and controls, there were no correlations among thyroid hormones and IGF-1 or IGFBP-3 levels, but GH levels were correlated with FT3, FT4 and TSH only in patients’ group. In controls, only IGF-1 and IGFBP-3 levels were correlated. The present study suggests that subclinical hypothyroidism with high TSH and antibody status does not affect IGF-1 and IGFBP-3 levels in adult women. To our knowledge, this is the first study concerning the relationship between autoimmune subclinical hypothyroidism and IGF-1 and IGFBP-3 levels.

Keywords

IGF-1 IGFBP-3 Autoimmune subclinical hypothyroidism