Central European Journal of Medicine

, Volume 6, Issue 2, pp 158–162

Serum IGF-1 and IGFBP-3 levels in subclinical hypothyroid women

Authors

    • Fikret Biyal Central Research Laboratory, Cerrahpasa Medical FacultyIstanbul University
  • Tijen Yesim Erdem
    • Division of Endocrinology-Metabolism and Diabetes and Department of MedicineHaseki Education and Research Hospital
  • Serdal Ugurlu
    • Division of Rheumatology, Department of Internal Medicine, Cerrahpasa Medical FacultyIstanbul University
  • Demet Ozgul Yetkin
    • Division of Endocrinology-Metabolism and Diabetes and Department of MedicineGoztepe Education and Research Hospital
  • I. Murat Bolayirli
    • Fikret Biyal Central Research Laboratory, Cerrahpasa Medical FacultyIstanbul University
  • Munire Hacibekiroglu
    • Fikret Biyal Central Research Laboratory, Cerrahpasa Medical FacultyIstanbul University
  • Ertugrul Tasan
    • Division of Endocrinology-Metabolism and Diabetes and Department of Medicine, Cerrahpasa Medical FacultyIstanbul University
Research Article

DOI: 10.2478/s11536-010-0036-3

Cite this article as:
Balci, H., Erdem, T.Y., Ugurlu, S. et al. cent.eur.j.med (2011) 6: 158. doi:10.2478/s11536-010-0036-3
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Abstract

Thyroid status is known to influence growth in mammals. The aim of this study is to investigate the possible relationship between autoimmune subclinical hypothyroidism and growth hormone (GH), insulin-like growth factor-1(IGF-1) and insulin-like growth factor binding protein-3(IGFBP-3) levels. Thirty-five women with autoimmune subclinical hypothyroidism, 33 years of age, were used as controls and enrolled in the study. Free triiodothyronin (FT3), free thyroxin(FT4), thyrotropin(TSH), anti-thyroid peroxidase(Anti-TPO), anti-thyroglobuline(Anti-Tg), GH, IGF-1 and IGFBP-3 levels were measured in blood samples and correlations among these parameters were evaluated. We found no significant differences in GH, IGF-1 or IGFBP-3 between patients and controls. In patients and controls, there were no correlations among thyroid hormones and IGF-1 or IGFBP-3 levels, but GH levels were correlated with FT3, FT4 and TSH only in patients’ group. In controls, only IGF-1 and IGFBP-3 levels were correlated. The present study suggests that subclinical hypothyroidism with high TSH and antibody status does not affect IGF-1 and IGFBP-3 levels in adult women. To our knowledge, this is the first study concerning the relationship between autoimmune subclinical hypothyroidism and IGF-1 and IGFBP-3 levels.

Keywords

IGF-1IGFBP-3Autoimmune subclinical hypothyroidism

Copyright information

© © Versita Warsaw and Springer-Verlag Berlin Heidelberg 2011