Research Article

Central European Journal of Chemistry

, Volume 8, Issue 3, pp 550-558

Synthesis, spectroscopic characterization, crystal structure and antifungal activity of thiourea derivatives containing a thiazole moiety

  • Sohail SaeedAffiliated withDepartment of Chemistry, Research Complex, Allama Iqbal Open University
  • , Naghmana RashidAffiliated withDepartment of Chemistry, Research Complex, Allama Iqbal Open University
  • , Peter G. JonesAffiliated withInstitut für Anorganische und Analytische Chemie, Technische Universität Braunschweig
  • , Rizwan HussainAffiliated withNational Engineering & Scientific Commission
  • , Moazzam Hussain BhattiAffiliated withDepartment of Chemistry, Research Complex, Allama Iqbal Open University

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Abstract

Four novel thiourea derivatives containing a thiazole moiety were synthesized and characterized by IR, 1H and 13C NMR, mass spectrometry and elemental analysis. The crystal structure of 1a was determined from single crystal X-ray diffraction data. It crystallizes in monoclinic space group P21/n with unit cell dimensions a = 11.7752(6) Å, b= 3.8677(2) Å, c= 27.4126(13) Å and β = 92.734(5) Å. There is a strong intramolecular hydrogen bond of the type N-H⋯O, with H⋯O distance of 2.5869(19) Å. The mass fragmentation pattern has also been discussed. The antifungal activity of the synthesized compounds was studied by broth micro-dilution method and poisoned food technique. The compounds 1b and 1c possessed a broad spectrum of antifungal activity.
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Keywords

Thiourea derivatives Thiazole X-ray structure determination Mass fragmentation Antifungal activity