Structural factors influencing the reaction rates of 4-aryloxy-7-nitrobenzofurazans with amino acids
- Cite this article as:
- Bem, M., Vasilescu, M., Caproiu, M.T. et al. cent.eur.j.chem. (2004) 2: 672. doi:10.2478/BF02482730
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An interesting observation was made when studying the SNAr reaction between several 4-aryloxy-7-nitrobenzofurazans (2) and several amino acids leading to the apparition of detectable fluorescence from the substitution products3. Acidic amino acids reacted very slowly=while basic amino acids react fastest with2 having an unsubstituted phenyl or a 4-formyl-phenyl Ar group. Amongst neutral amino acids, proline reacts fastest at room temperature after 100 min. With2 having a methoxy-subtituted Ar group.