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Selected risk factors of fractures in children — own observation

  • Research Article
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Central European Journal of Medicine

Abstract

Bone fractures may depend on Vitamin D Receptor Gene (VDR), bone mineral density, bone turnover markers. Patients and methods. 161 patients were recruited and underwent: skeletal densitometry (DXA) method and bone turnover studies (Osteocalcin and Ntx).The study group was evaluated using restriction enzyme digestion at BsmI (rs1544410), FokI (rs2228570), ApaI (rs7975232) and TaqI (rs731236), polymorphic sites of the VDR gene. Multivariate logistic regression was used to assess factor significance. The model included variables with sex- and age-standardized parameters, VDR genotypes, and bone metabolism marker levels. Results. Factors associated with fractures were: osteocalcin concentration and Z-score BMDt. Odds Ratio (OR) values equaled: 1.01 (95%Confidence Interval (95%CI) 1.00–1.02) for osteocalcin (p=0.006), and 0.66 (95%CI 0.42-1.03; p=0.07) for Z-score BMDt. In patients with reduced bone mass, factors related to fractures were: osteocalcin (0.04) and carriage of BsmI b (0.07) or ApaI a alleles (0.08). ORs were 1.01 (95%CI 1.00–1.02) for OC, 0.29 (95%CI 0.07–1.14) for BsmI, and 2.13 (95%CI 0.91–4.99) for ApaI polymorphic allele carriage. Conclusions. Carriage of BsmI b allele reduces, while carriage of ApaI a allele and heightened osteoclacin level increase the risk of fractures in study children with reduced bone mass. VDR polymorphism, bone mineral density and bone formation’s marker — osteocalcin maybe considered as risk factor for fracure in children from Lodz region.

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Authors and Affiliations

  1. Department of Paediatric Propedeutics and Bone Metabolism Diseases, Medical University of Lodz, 36/50 Sporna St, 91-738, Lodz, Poland

    Elżbieta Jakubowska-Pietkiewicz & Danuta Chlebna-Sokół

  2. Department of Pediatrics, Oncology, Hematology and Diabetology, Medical University of Lodz, 36/50 Sporna St, 91-738, Lodz, Poland

    Wojciech Fendler, Wojciech Młynarski & Izabela Klich

Authors
  1. Elżbieta Jakubowska-Pietkiewicz
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  2. Wojciech Fendler
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  3. Wojciech Młynarski
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  4. Izabela Klich
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  5. Danuta Chlebna-Sokół
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Correspondence to Elżbieta Jakubowska-Pietkiewicz.

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Jakubowska-Pietkiewicz, E., Fendler, W., Młynarski, W. et al. Selected risk factors of fractures in children — own observation. cent.eur.j.med 7, 635–641 (2012). https://doi.org/10.2478/s11536-012-0045-5

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  • DOI: https://doi.org/10.2478/s11536-012-0045-5

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