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Synthesis, spectroscopic characterization, crystal structure and antifungal activity of thiourea derivatives containing a thiazole moiety

  • Research Article
  • Published:
Central European Journal of Chemistry

Abstract

Four novel thiourea derivatives containing a thiazole moiety were synthesized and characterized by IR, 1H and 13C NMR, mass spectrometry and elemental analysis. The crystal structure of 1a was determined from single crystal X-ray diffraction data. It crystallizes in monoclinic space group P21/n with unit cell dimensions a = 11.7752(6) Å, b= 3.8677(2) Å, c= 27.4126(13) Å and β = 92.734(5) Å. There is a strong intramolecular hydrogen bond of the type N-H⋯O, with H⋯O distance of 2.5869(19) Å. The mass fragmentation pattern has also been discussed. The antifungal activity of the synthesized compounds was studied by broth micro-dilution method and poisoned food technique. The compounds 1b and 1c possessed a broad spectrum of antifungal activity.

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Authors and Affiliations

  1. Department of Chemistry, Research Complex, Allama Iqbal Open University, Islamabad, Pakistan

    Sohail Saeed, Naghmana Rashid & Moazzam Hussain Bhatti

  2. Institut für Anorganische und Analytische Chemie, Technische Universität Braunschweig, Postfach 3329, 38023, Braunschweig, Germany

    Peter G. Jones

  3. National Engineering & Scientific Commission, P.O. Box 2801, Islamabad, Pakistan

    Rizwan Hussain

Authors
  1. Sohail Saeed
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  2. Naghmana Rashid
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  3. Peter G. Jones
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  4. Rizwan Hussain
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  5. Moazzam Hussain Bhatti
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Saeed, S., Rashid, N., Jones, P.G. et al. Synthesis, spectroscopic characterization, crystal structure and antifungal activity of thiourea derivatives containing a thiazole moiety. cent.eur.j.chem. 8, 550–558 (2010). https://doi.org/10.2478/s11532-010-0014-2

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  • DOI: https://doi.org/10.2478/s11532-010-0014-2

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