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G Protein-Coupled Receptor Kinases and Hypertension

A Review of Disease Mechanisms

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Abstract

The understanding of molecular mechanisms of complex physiological phenomena, such as cardiac contractile function or blood pressure homeostasis, has generated the need for a new generation of scientists who must be able to conjugate intrinsic biological mechanisms and clinical manifestations of disease. From this body of knowledge new strategies of disease management or therapeutic tools are derived, creating the ground for translational medicine, which provides the bridge from basic science to the medical arena. The investigation of G protein-coupled receptor kinases in the cardiovascular system is one example of the successful transposition of basic science to the field of heart and vascular disorders.

This review attempts to assemble the currently available information in this continuing area of research for the class of scientists now referred to as ‘translational researchers’.

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Acknowledgements

Guido Iaccarino is supported by MIUR grant 2004069479_002. The authors have no conflicts of interest that are directly relevant to the content of this review.

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Authors and Affiliations

  1. Department of Clincal Medicine and Cardiovascular and Immunological Sciences, University of Naples ‘Federico II’, Naples, Italy

    Guido Iaccarino, Alfonso Campanile, Gaetano Santulli & Francesco Zuppieri

  2. Department of Medicine, Center for Translational Medicine, Jefferson Medical College, Thomas Jefferson University, 1025 Walnut Street, Room 317, Philadelphia, Pennsylvania, 19107, USA

    Guido Iaccarino &  Walter J. Koch (Director, Vice Chairman)

Authors
  1. Guido Iaccarino
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  2. Alfonso Campanile
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  3. Gaetano Santulli
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  4. Francesco Zuppieri
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  5. Walter J. Koch
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Correspondence to Walter J. Koch.

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Iaccarino, G., Campanile, A., Santulli, G. et al. G Protein-Coupled Receptor Kinases and Hypertension. High Blood Press Cardiovasc Prev 13, 151–158 (2006). https://doi.org/10.2165/00151642-200613040-00002

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