Review Article

Drugs in R&D

, Volume 12, Issue 4, pp 227-233

First online:

Open Access This content is freely available online to anyone, anywhere at any time.

Radium-223 Chloride

A New Treatment Option for Metastatic Castration-Resistant Prostate Carcinoma
  • Álvaro PintoAffiliated withMedical Oncology Department, University Hospital La Paz - IdiPAZ Email author 
  • , Patricia CruzAffiliated withMedical Oncology Department, University Hospital La Paz - IdiPAZ


In the last few years, the treatment of castration-resistant prostate carcinoma (CRPC) has changed completely. The approval of docetaxel and subsequent investigation in this field have led to development of new agents that have demonstrated an improvement in overall survival in the post-docetaxel setting, such as cabazitaxel and abiraterone. Radium-223 chloride is a radioisotope that has recently shown efficacy after docetaxel and in patients unfit for docetaxel, with improvements in overall survival and the time to the first skeletal-related event, compared with placebo, without increasing toxicity. These findings have made this agent a new option for treatment of these patients in the near future.