American Journal of Clinical Dermatology

, Volume 13, Issue 3, pp 141–152

Topical Antimicrobial Treatment of Acne Vulgaris

An Evidence-Based Review
  • Ryan Gamble
  • Jeff Dunn
  • Annelise Dawson
  • Brian Petersen
  • Lauren McLaughlin
  • Alison Small
  • Scott Kindle
  • Robert P. Dellavalle
Evidence-based Review Article

DOI: 10.2165/11597880-000000000-00000

Cite this article as:
Gamble, R., Dunn, J., Dawson, A. et al. Am J Clin Dermatol (2012) 13: 141. doi:10.2165/11597880-000000000-00000

Abstract

Topical antimicrobial treatment is indicated for mild to moderate acne vulgaris. Our literature review includes searches of Ovid, MEDLINE, EMBASE, and the databases of the Cochrane Library. A detailed search strategy is included. All searches were limited to controlled trials and systematic reviews. No year limits were applied to the searches, but we focused on trials, guidelines, and reviews published since 2004, the year that the last review of topical antimicrobials was published in this journal. Several controlled trials demonstrate that benzoyl peroxide, topical antibiotics, and topical retinoids used in combination provide the greatest efficacy and safety profile for the treatment of mild to moderate acne, but there are few trials directly comparing different combinations of these topical therapies with one another. Additionally, robust studies comparing cost and efficacy of generic combinations of the above agents with proprietary fixed-dose combination therapies that may increase compliance are also lacking. Although they have not been extensively studied, alternative agents including dapsone, salicylic acid, azelaic acid, and zinc are safe and efficacious when combined with traditional therapies.

Supplementary material

40257_2012_13030141_MOESM1_ESM.pdf (79 kb)
Supplementary material, approximately 80 KB.
40257_2012_13030141_MOESM2_ESM.pdf (45 kb)
Supplementary material, approximately 46 KB.

Copyright information

© Adis Data Information BV 2012

Authors and Affiliations

  • Ryan Gamble
    • 1
  • Jeff Dunn
    • 1
  • Annelise Dawson
    • 1
  • Brian Petersen
    • 1
  • Lauren McLaughlin
    • 2
  • Alison Small
    • 3
  • Scott Kindle
    • 4
  • Robert P. Dellavalle
    • 1
    • 5
  1. 1.School of MedicineUniversity of ColoradoAuroraUSA
  2. 2.College of Osteopathic MedicineRocky Vista UniversityParkerUSA
  3. 3.College of MedicineUniversity of ArizonaTucsonUSA
  4. 4.College of MedicineUniversity of NebraskaOmahaUSA
  5. 5.Dermatology ServiceDepartment of Veterans Affairs Medical CenterDenverUSA