Drugs & Aging

, Volume 27, Issue 5, pp 351–365

Targeting Tau Protein in Alzheimer’s Disease

Leading Article

DOI: 10.2165/11536110-000000000-00000

Cite this article as:
Gong, CX., Grundke-Iqbal, I. & Iqbal, K. Drugs Aging (2010) 27: 351. doi:10.2165/11536110-000000000-00000

Abstract

Alzheimer’s disease (AD) is characterized histopathologically by numerous neurons with neurofibrillary tangles and neuritic (senile) amyloid-β (Aβ) plaques, and clinically by progressive dementia. Although Aβ is the primary trigger of AD according to the amyloid cascade hypothesis, neurofibrillary degeneration of abnormally hyperphosphorylated tau is apparently required for the clinical expression of this disease. Furthermore, while approximately 30% of normal aged individuals have as much compact plaque burden in the neocortex as is seen in typical cases of AD, in several tauopathies, such as cortical basal degeneration and Pick’s disease, neurofibrillary degeneration of abnormally hyperphosphorylated tau in the absence of Aβ plaques is associated with dementia. To date, all AD clinical trials based on Aβ as a therapeutic target have failed. In addition to the clinical pathological correlation of neurofibrillary degeneration with dementia in AD and related tauopathies, increasing evidence from in vitro and in vivo studies in experimental animal models provides a compelling case for this lesion as a promising therapeutic target. A number of rational approaches to inhibiting neurofibrillary degeneration include inhibition of one or more tau protein kinases, such as glycogen synthase kinase-3β and cyclin-dependent protein kinase 5, activation of the major tau phosphatase protein phosphatase-2A, elevation of β-N-acetyl-glucosamine modification of tau through inhibition of β-N-acetylglucosaminidase or increase in brain glucose uptake, and promotion of the clearance of the abnormally hyperphosphorylated tau by autophagy or the ubiquitin proteasome system.

Copyright information

© Adis Data Information BV 2010

Authors and Affiliations

  • Cheng-Xin Gong
    • 1
  • Inge Grundke-Iqbal
    • 1
  • Khalid Iqbal
    • 1
  1. 1.Department of NeurochemistryNew York State Institute for Basic Research in Developmental DisabilitiesStaten IslandUSA

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