Clinical Pharmacokinetics

, Volume 49, Issue 7, pp 449–454

Steady-State Pharmacokinetics and Tolerability of Trans-Resveratrol 2000mg Twice Daily with Food, Quercetin and Alcohol (Ethanol) in Healthy Human Subjects


    • The Ottawa Hospital Research Institute
    • University of Ottawa
  • Nha Voduc
    • University of Ottawa
  • Guijun Zhang
    • The Ottawa Hospital Research Institute
  • Isabelle Seguin
    • The Ottawa Hospital Research Institute
  • Danielle Tardiff
    • The Ottawa Hospital Research Institute
  • Neera Singhal
    • The Ottawa Hospital Research Institute
    • University of Ottawa
  • D. William Cameron
    • The Ottawa Hospital Research Institute
    • University of Ottawa
Original Research Article

DOI: 10.2165/11531820-000000000-00000

Cite this article as:
la Porte, C., Voduc, N., Zhang, G. et al. Clin Pharmacokinet (2010) 49: 449. doi:10.2165/11531820-000000000-00000


Background and Objective

Trans-resveratrol is a polyphenol, which is found in red wine and has cancer chemo-preventive properties and disease-preventive properties. The pharmacokinetics of trans-resveratrol have been investigated in single-dose studies and in studies with relatively low dosages. The present study aimed to investigate the steady-state pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol).


This was a two-period, open-label, single-arm, within-subject control study in eight healthy subjects. The steady-state 12-hour pharmacokinetics of trans-resveratrol 2000 mg twice daily were studied with a standard breakfast, a high-fat breakfast, quercetin 500 mg twice daily and 5% alcohol 100 mL. Trans-resveratrol plasma concentrations were determined using liquid chromatography with tandem mass spectrometry.


The mean (SD) area under the plasma concentration-time curve from 0 to 12 hours (AUC12) and maximum plasma concentration (Cmax) of trans-resveratrol were 3558 (2195) ng •h/mL and 1274 (790) ng/mL, respectively, after the standard breakfast. The high-fat breakfast significantly decreased the AUC12 and Cmax by 45% and 46%, respectively, when compared with the standard breakfast. Quercetin 500 mg twice daily or 5% alcohol 100mL did not influence trans-resveratrol pharmacokinetics. Diarrhoea was reported in six of the eight subjects. Significant but not clinically relevant changes from baseline were observed in serum potassium and total bilirubin levels.


Trans-resveratrol 2000 mg twice daily resulted in adequate exposure and was well tolerated by healthy subjects, although diarrhoea was frequently observed. In order to maximize trans-resveratrol exposure, it should be taken with a standard breakfast and not with a high-fat meal. Furthermore, combined intake with quercetin or alcohol did not influence trans-resveratrol exposure.

Copyright information

© Adis Data Information BV 2010