Ezetimibe/Simvastatin: A Guide to its Clinical Use in Hypercholesterolemia
- First Online:
- Cite this article as:
- Lyseng-Williamson, K.A. Am J Cardiovasc Drugs (2012) 12: 49. doi:10.2165/11209150-000000000-00000
- 123 Views
Ezetimibe/simvastatin therapy combines two lipid-lowering compounds with complementary mechanisms of action, thereby blocking the two sources of plasma cholesterol and improving lipid profiles. Ezetimibe/simvastatin is an effective and generally well tolerated adjunct to dietary therapy for markedly reducing lowdensity lipoprotein cholesterol (LDL-C) levels and improving other lipid parameters across diverse patient populations. Dual treatment with ezetimibe/simvastatin is more effective than monotherapy with an HMG-CoA reductase inhibitor (statin), and the addition of ezetimibe to current statin therapy is more effective than doubling the statin dose.