Evidence-Based Integrative Medicine

, Volume 2, Issue 1, pp 13–18

Green Tea Polyphenols

Promising Substances for Prostate Cancer Chemoprevention
Review Article

DOI: 10.2165/01197065-200502010-00004

Cite this article as:
Kumar, N.B. Evid-Based-Integrative-Med (2005) 2: 13. doi:10.2165/01197065-200502010-00004
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Abstract

Basic research has identified some nutrients as agents that inhibit mutagenesis and hyperproliferation, as well as some that induce apoptosis or differentiation, which are critical characteristics for chemoprevention regardless of the nutrient’s specific molecular targets. Some of the most promising nutrients identified as chemopreventive agents in prostate cancer are green tea polyphenols. The components of green tea are epigallocatechin-3-gallate [(−)-EGCG], epigallocatechin [(−)-EGC], epicatechin-3-gallate [(−)-ECG], epicatechin [(−)-EC] and their epimers (−)-GCG, (−)-CG, (−)-GC and (−)-C. Of these components, (−)-EGCG has been the most extensively investigated because of its relative abundance and strong cancer-preventive properties. Recently, several epidemiological, animal and laboratory studies have demonstrated the cancer-preventive properties of green tea polyphenols, specifically in prostate cancer. This article reviews the evidence to date in the role of green tea polyphenols in prostate cancer, and the future directions of this field of research.

Copyright information

© Adis Data Information BV 2005

Authors and Affiliations

  1. 1.Department of Nutrition and Department of Cancer Control, H. Lee Moffitt Cancer Center and Research InstituteUniversity of South Florida College of MedicineTampaUSA