Disease Management & Health Outcomes

, Volume 16, Issue 6, pp 403–410

Antimicrobial Stewardship Programs

Role in Optimizing Infectious Disease Outcomes
Review Article

DOI: 10.2165/0115677-200816060-00005

Cite this article as:
Kubin, C.J. Dis-Manage-Health-Outcomes (2008) 16: 403. doi:10.2165/0115677-200816060-00005


Given increasing trends in antimicrobial resistance and the resulting limited treatment options, the treatment of hospital-acquired infections poses a significant challenge to healthcare providers. Optimization and conservation of current antimicrobials are necessary. Antimicrobial stewardship programs aim to optimize the use of antimicrobial agents through a multidisciplinary effort utilizing different strategies (prospective audit and feedback, formulary restriction and preauthorization, education, guidelines and clinical pathways, antimicrobial order forms, de-escalation, pharmacokinetic/pharmacodynamic dose optimization) either alone or in combination. Effective antimicrobial stewardship programs are proactive, sustainable, and capable of optimizing antimicrobial choices, dosages, and durations to decrease the emergence of antimicrobial resistance. Hospital resources and personnel dictate the most feasible strategies to achieve these outcomes.

Copyright information

© Adis Data Information BV 2008

Authors and Affiliations

  1. 1.Division of Infectious DiseasesColumbia University College of Physicians and SurgeonsNew YorkUSA
  2. 2.New York-Presbyterian HospitalColumbia University Medical CenterNew YorkUSA