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- Xu, Q. & Shaulsky, G. Appl-Bioinformatics (2005) 4: 281. doi:10.2165/00822942-200504040-00008
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Understanding the composition of gene lists that result from high-throughput experiments requires elaborate processing of gene annotation lists. In this article we present GOAT (Gene Ontology Analysis Tool), a tool based on the statistical software ‘R’ for analysing Gene Ontology™ (GO) term enrichment in gene lists. Given a gene list, GOAT calculates the enrichment and statistical significance of every GO term and generates graphical presentations of significantly enriched terms. GOAT works for any organism with a genome-scale GO annotation and allows easy updates of ontologies and annotations.