Applied Bioinformatics

, Volume 4, Issue 4, pp 281–283


An R Tool for Analysing Gene Ontology™ Term Enrichment
Application Note

DOI: 10.2165/00822942-200504040-00008

Cite this article as:
Xu, Q. & Shaulsky, G. Appl-Bioinformatics (2005) 4: 281. doi:10.2165/00822942-200504040-00008


Understanding the composition of gene lists that result from high-throughput experiments requires elaborate processing of gene annotation lists. In this article we present GOAT (Gene Ontology Analysis Tool), a tool based on the statistical software ‘R’ for analysing Gene Ontology™ (GO) term enrichment in gene lists. Given a gene list, GOAT calculates the enrichment and statistical significance of every GO term and generates graphical presentations of significantly enriched terms. GOAT works for any organism with a genome-scale GO annotation and allows easy updates of ontologies and annotations.

Copyright information

© Adis Data Information BV 2005

Authors and Affiliations

  1. 1.Graduate Program in Structural and Computational Biology and Molecular BiophysicsBaylor College of MedicineHoustonUSA
  2. 2.Department of Molecular and Human GeneticsBaylor College of MedicineHoustonUSA