American Journal of Pharmacogenomics

, Volume 3, Issue 5, pp 345–353

Beyond the Human Genome

Examples of Nuclear Receptor Analysis in Model Organisms and Potential for Drug Discovery
  • Jodi M. Maglich
  • Ann E. Sluder
  • Tim M. Willson
  • John T. Moore
Genomics in Drug Development

DOI: 10.2165/00129785-200303050-00005

Cite this article as:
Maglich, J.M., Sluder, A.E., Willson, T.M. et al. Am J Pharmacogenomics (2003) 3: 345. doi:10.2165/00129785-200303050-00005

Abstract

The nuclear receptor (NR) superfamily is a large group of related, pharmacologically important receptors, comprising the targets for over 10% of commonly prescribed drugs. Cross-genome analysis of NR sequence, structure, and biological function, provides an important source of information on the function of human NRs and thus plays a role in NR drug discovery. For example, research on the pregnane X receptor (PXR; NR1I2), constitutive androstane receptor (CAR; NR1I3), hepatocyte nuclear factor 4 (HNF4; NR2A1), and farnesoid X receptor (FXR) illustrate how the study of nonhuman orthologs has provided new insights into NR biology and has increased our understanding of human NRs and orphan NR function. Understanding differences between humans and pharmacological model species may provide useful tools for the development of new NR-binding drugs.

Copyright information

© Adis Data Information BV 2003

Authors and Affiliations

  • Jodi M. Maglich
    • 1
  • Ann E. Sluder
    • 2
  • Tim M. Willson
    • 1
  • John T. Moore
    • 1
    • 2
  1. 1.Nuclear Receptor Discovery ResearchGlaxoSmithKlineResearch Triangle ParkUSA
  2. 2.Cambria BiosciencesBedfordUSA