American Journal of Cardiovascular Drugs

, Volume 8, Issue 4, pp 219–231

Management of Ischemic Heart Disease in Patients with Chronic Kidney Disease


  • Arif Mutwali
    • Department of Medicine, Division of NephrologyNational University of Ireland
  • Liam G. Glynn
    • Department of General PracticeNational University of Ireland
    • Department of Medicine, Division of NephrologyNational University of Ireland
    • Unit 1Merlin Park University Hospital
Review Article

DOI: 10.2165/00129784-200808040-00002

Cite this article as:
Mutwali, A., Glynn, L.G. & Reddan, D. Am J Cardiovasc Drugs (2008) 8: 219. doi:10.2165/00129784-200808040-00002


Patients with chronic kidney disease (CKD) and ischemic heart disease (IHD) have strikingly high mortality rates. In the general population, there has been a reduction in the mortality and morbidity rates for IHD through the implementation of effective risk-factor-reduction programs and better interventions for patients with established IHD. No such trend has been observed in patients with end-stage kidney disease.

This review article addresses the following topics: (i) epedemiology, pathogenesis, clinical CKD patients with IHD; (ii) diagnostic modalities for IHD and their limitation in CKD patients; (iii) medical treatment options and revascularization strategies for these high-risk patients; and (iv) optimal cardiovascular risk management. Generally, in CKD patients with IHD an aggressive approach to IHD is warranted, a low threshold for diagnostic testing should be employed, and awaiting a clinical trial targeting these patients they should be considered for all proven strategies to improve outcomes.

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© Adis Data Information BV 2008