Paediatric Drugs

, Volume 3, Issue 12, pp 863–881

Pharmacogenetic Tactics and Strategies

Implications for Paediatrics
Leading Article

DOI: 10.2165/00128072-200103120-00001

Cite this article as:
Weber, W.W. Paediatr Drugs (2001) 3: 863. doi:10.2165/00128072-200103120-00001

Abstract

Genetic diversity exerts profound effects on variation in human drug response in adults, but comparatively little research that specifically relates to genetically abnormal responses in infancy and childhood has been reported. Specific genetic changes in human enzymes, receptors and other proteins that are implicated in drug response and their associated phenotypic correlates provide needed data for construction of profiles individualised to predict susceptibility to adverse drug reactions. If therapy adheres to such guidelines, failure to respond to drug therapy and drug toxicity among genetically susceptible persons can be greatly minimised or averted.

Copyright information

© Adis International Limited 2001

Authors and Affiliations

  1. 1.Room 1301b MSRB III, Department of PharmacologyUniversity of MichiganAnn ArborUSA