BioDrugs

, Volume 22, Issue 4, pp 265–273

Autologous T-Cell Vaccination for Multiple Sclerosis

A Perspective on Progress
Novel Therapeutic Strategies

DOI: 10.2165/00063030-200822040-00006

Cite this article as:
Vandenbark, A.A. & Abulafia-Lapid, R. BioDrugs (2008) 22: 265. doi:10.2165/00063030-200822040-00006

Abstract

T-cell vaccination (TCV) is a unique approach to induce immune regulation that may have importance in the treatment of autoimmune diseases, including multiple sclerosis (MS). TCV employs a classic vaccine strategy of injecting an attenuated form of the disease-causing agent — in this case, myelin-reactive T cells — that have been selected and expanded from each MS donor and then re-injected after irradiation to induce protective immunity. This anti-T-cell immunity consistently results in selective deletion or regulation of the targeted pathogenic T cells in vivo. Longitudinal studies have established that TCV is safe and often results in a reduced relapse rate and clinical stability or improvement, at least temporarily, in the majority of treated MS patients. These results lend direct support to the involvement of inflammatory myelin-reactive T cells in the MS disease process. However, these hopeful trends reported in a number of pilot trials await validation in larger proof-of-principle trials that are now in progress.

Copyright information

© Adis Data Information BV 2008

Authors and Affiliations

  1. 1.Neuroimmunology Research R&D-31Veterans Affairs Medical CenterPortlandUSA
  2. 2.Department of NeurologyOregon Health & Science UniversityPortlandUSA
  3. 3.Department of Molecular Microbiology and ImmunologyOregon Health & Science UniversityPortlandUSA
  4. 4.Human Biology Research Center (HBRC)Hadassah University HospitalJerusalemIsrael