, Volume 20, Issue 6, pp 351–356

BioMEMS Sensor Systems for Bacterial Infection Detection

Progress and Potential

DOI: 10.2165/00063030-200620060-00005

Cite this article as:
Ivanov, D. BioDrugs (2006) 20: 351. doi:10.2165/00063030-200620060-00005


The spread of drug-resistant bacteria represents a growing worldwide health problem. The most efficient way to fight drug-resistant bacteria is to detect their colonies, identify their type, monitor their growth, and destroy them before they reach the human body. A gravimetric biomedical micro-electro-mechanical sensor (BioMEMS) system operating in the pico-gram range (10−12 g/cm2) has been proposed for detecting growth of drug-resistant bacterial colonies. The sensor is based on a MEMS metal-coated thin piezoelectric membrane resonator. A combination of shear horizontal surface acoustic (SHSAW), Bleustein-Gulyaev, skimming and ‘leaky’ waves, generated in the resonator, are highly sensitive to mass, density, viscoelastic, and electrochemical changes at the resonator/bacteria interface. Measuring resonant frequency shifts of the composite resonator provides information about the mass and type of the bacterium colony growing on the resonator.

Copyright information

© Adis Data Information BV 2006

Authors and Affiliations

  1. 1.Microelectronics Fabrication CenterNew Jersey Institute of TechnologyNewark R200USA