BioDrugs

, Volume 20, Issue 5, pp 271–273

The Pro-Oxidant Activity of High-Dose Vitamin E Supplements in Vivo

Authors

  • Philip Pearson
    • Division of Respiratory MedicineUniversity of Nottingham, Nottingham City Hospital
  • Sarah A. Lewis
    • Division of Respiratory MedicineUniversity of Nottingham, Nottingham City Hospital
  • John Britton
    • Division of Epidemiology and Public HealthUniversity of Nottingham, Nottingham City Hospital, Clinical Science Building
  • Ian S. Young
    • Queen’s University Belfast, Welcome Research Laboratories, Royal Victoria Hospital
    • Division of Epidemiology and Public HealthUniversity of Nottingham, Nottingham City Hospital, Clinical Science Building
Short Communication

DOI: 10.2165/00063030-200620050-00002

Cite this article as:
Pearson, P., Lewis, S.A., Britton, J. et al. BioDrugs (2006) 20: 271. doi:10.2165/00063030-200620050-00002

Abstract

Background

A recent meta-analysis has demonstrated that the regular administration of high-dose vitamin E supplements may be associated with increased mortality. The biological mechanism for this effect is uncertain.

Methods

A ferrous oxidation xylenol assay was used to assess plasma oxidation activity levels in samples from a randomized, placebo-controlled, 6-week trial of daily vitamin E supplementation in adults with asthma (n = 72).

Results and conclusion

27% increase in plasma oxidation activity levels was observed in patients receiving vitamin E. We demonstrate a pro-oxidant effect of high-dose vitamin E supplementation that may explain the increase in mortality observed in intervention studies using this nutrient.

Copyright information

© Adis Data Information BV 2006