Clinical Drug Investigation

, Volume 16, Issue 5, pp 355–360

Highly Effective Oral Therapy Polyethylene Glycol/Electrolyte Solution for Faecal Impaction and Severe Constipation

Clinical Use

DOI: 10.2165/00044011-199816050-00002

Cite this article as:
Culbert, P., Gillett, H. & Ferguson, A. Clin. Drug Investig. (1998) 16: 355. doi:10.2165/00044011-199816050-00002

Abstract

Objective: To investigate the efficacy and tolerability of polyethylene glycol/ electrolyte solution (Movicol®, Norgine Ltd) therapy in patients with faecal impaction and severe constipation.

Patients: 16 inpatients (aged 26 to 87 years) and 14 outpatients (aged 17 to 61 years) with a history of chronic constipation, who had not had a bowel motion for 5 or more days and had faecal loading confirmed by clinical examination, were enrolled in this open study in a large general, teaching hospital in Edinburgh, Scotland. Patients who were completely bedridden, or had suspected intestinal obstruction or severe inflammatory bowel disease were excluded.

Intervention: Each daily treatment consisted of 1 litre of Movicol, administered as two 500ml portions to be taken within 4 to 6 hours.

Outcome Measures and Results: Relief of impaction was strictly defined as passage of a large or moderate volume of stool together with disappearance of previously palpable faecal masses in the abdomen and/or rectum. Complete resolution of constipation or impaction was obtained in 13 patients after 1 day, 11 more after 2 days and one more after 3 days. All other patients were significantly improved. The only symptom significantly associated with the treatment was abdominal rumbling, evidence of the action of the drug in stimulating colonic motility.

Conclusion: Movicol, given as a treatment dose equivalent to eight sachets (1 litre) daily for up to 3 days, was a highly effective and acceptable oral therapy for faecal impaction.

Copyright information

© Adis International Limited 1998

Authors and Affiliations

  1. 1.Gastrointestinal UnitUniversity of Edinburgh Department of Medicine, Western General HospitalEdinburghScotland
  2. 2.Gastrointestinal LaboratoryWestern General HospitalEdinburghScotland