, Volume 24, Issue 5, pp 17-20
Date: 30 Aug 2012

Persistence is the key to treating nonpsychotic major depressive disorder in elderly patients

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Response to initial antidepressant pharmacotherapy is only achieved in ≈50% of elderly patients with nonpsychotic major depressive disorder. When response to persistent initial treatment is incomplete, switching to another antidepressant agent is just as effective as augmenting therapy with another agent, while also being less expensive, safer and associated with better compliance. Combination therapy should be reserved for repeat nonresponders to monotherapy. Nonpharmacological measures also play an important role.

Depression in elderly a health priority

Nonpsychotic major depressive disorder is prevalent in later life and, with an increasingly larger elderly population, has become a major public health priority.[1] Consequences of late-life major depressive disorder include acceleration of functional and cognitive decline, disability amplification, increased hospitalization, reduced health-related quality of life and a greater burden placed on caregivers. Mortality from associated co-m ...