Treatments in Endocrinology

, Volume 4, Issue 1, pp 55–64

Surgical Management of Obesity

A Review of Their Effects on Glucose Metabolism and Insulin Resistance


  • Michael D. Lara
    • Department of General and Vascular SurgeryGundersen Lutheran Medical Center
    • Department of General and Vascular SurgeryGundersen Lutheran Medical Center
  • Harvey J. Sugerman
    • Division of General/Trauma Surgery, Medical College of VirginiaVirginia Commonwealth University
Review Article

DOI: 10.2165/00024677-200504010-00006

Cite this article as:
Lara, M.D., Kothari, S.N. & Sugerman, H.J. Mol Diag Ther (2005) 4: 55. doi:10.2165/00024677-200504010-00006


Obesity continues to plague our society in epidemic proportions. Surgery for morbid obesity is considered by many as the most effective therapy for this complex disorder. Today, multiple surgical procedures for the treatment of obesity are available. As with most procedures, there are benefits and risks associated with open and laparoscopic gastric bypass surgery, as well as with laparoscopic adjustable gastric banding and partial biliopancreatic bypass with a duodenal switch. The risks and complications associated with bariatric surgery may be serious and in some cases life threatening. However, surgery for obesity has shown remarkable results in helping patients to achieve significant long-term weight control. In addition, it is associated with improvement and often resolution of co-morbid conditions, including type 2 diabetes mellitus, systemic hypertension, obesity hypoventilation, sleep apnea, venous stasis disease, pseudotumor cerebri, polycystic ovary syndrome, complications of pregnancy and delivery, gastroesophageal reflux disease, stress urinary incontinence, degenerative joint disease, and non-alcoholic steatohepatitis.

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© Adis Data Information BV 2005